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Arachidonate 15 lipoxygenase is required for chronic myeloid leukemia stem cell survival

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Figure

Figure 1. Alox15Alox15cells by retroviral transduction, followed by transplantation of the transduced cells into recipient mice
Figure 2. Loss of Alox15than that of CD45.2CMP, GMP, and MEP cells in the BM of CML mice ( impairs LSC function
Figure 3. Inhibition of Alox15or PD146176, and at day 14 after CML induction, the percentages of BM LSCs in the treated CML mice were compared
Figure 4. Inhibitory effect of PD146176 on LSCs. (PD146176 in vitro (were treated with PD146176 for 48 or 72 hours and plated into stem cell methocult media
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