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Large scale genomic reorganization of topological domains at the HoxD locus

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Figure

Fig. 1 Interactions at the HoxD locus as seen by 3D DNA FISH and 4C-seq. a 4C interaction profiles (normalized signals) of Hoxd13 in wild-typeautopod (AP, blue) and zeugopod (ZP, red) cells, isolated from E12.5 embryonic mouse forelimb
Fig. 2 Tripartite interactions betweenregion generated from 4C-seq data using400 nm.Hoxd13 Hoxd13 and the regulatory islands
Fig. 3 Impact of increasing distance on interactions withFISH signals fortwo large inversions
Fig. 4 Impact of large inversions on transcription.island II as a viewpoint ( a Two large inversions displacing regulatory islands away from Hoxd13
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