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Sustainable Syntheses of (−) Jerantinines A & E and Structural Characterisation of the Jerantinine Tubulin Complex at the Colchicine Binding Site

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Figure

Figure 1. A selection of Vinca and Aspidosperma alkaloids.
Table 1. GI50 values of natural product and synthetic jerantinine A (1) and colchicine against human-derived colorectal (HCT116) and mammary (MCF-7) carcinoma cell lines
Figure 3. (colonies forming after 8 d incubation was determined. Mean (from paclitaxel (5 showing the effect on microtubules (green) and the cellular DNA (purple)
Figure 5. Crystal structure of the tubulin-jerantinine B acetate (TTL-jerantinine B acetate complex structure

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