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Prevention of adoptively transferred diabetes in nonobese diabetic mice with IL 10 transduced islet specific Th1 lymphocytes A gene therapy model for autoimmune diabetes

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Figure

Figure 1. RT-PCR detection of cytokine mRNAs in wild type Th1 clones and IL-10–transduced Th1 cells
Figure 4. Schematic presentation of a retroviral vector construct. A 5.2 kbp retroviral vector of pBabe Neo contains a stretch of Mo-MLV 5� and 3�-LTRs, an SR� promoter (640 bp), mIL-10 cDNA (600 bp), and the neomycin phosphotransferase gene (1165 bp).
Figure 5. PCR-detection of the Neo gene. DNA was extracted from wild type Th1 clones, IL-10–transduced Th1 cells, and two recipient islet preparations from mouse No
Table II. Distribution of Islets Among Four Insulitis Grades
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