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Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism

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Figure

Figure 1Generation of Cyp3a
Figure 2CYP3A4 expression in transgenic mice. (
Figure 3Metabolism of docetaxel in microsomal fractions derived from liver (A) or intestine (B) of wild-type, Cyp3a–/–, Cyp3a–/–A, and Cyp3a–/–V mice
Figure 4Cyp3a limits docetaxel exposure. Expression of CYP3A4 in intestine virtually blocks docetaxel entry upon oral administration, whereas liver CYP3A4 expres-sion predominantly limits systemic exposure
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