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Hypoxia promotes fibrogenesis in vivo via HIF 1 stimulation of epithelial to mesenchymal transition

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Academic year: 2020

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Figure

Figure 1Hypoxia induces morphological and phenotypic changes in PTECs
Figure 2Hif-1 promotes EMT in PTECs. (A) Upper-left panel: Schematic illustrating the genetic make-up of mice used for the in vitro EMT studies
Figure 3Hif-1 enhances epithelial cell migration through induction of lysyl oxidases. (A) Hif1a+/+ or Hif1a–/– PTECs were cultured under normoxia or hypoxia for 6 days
Figure 4UUO kidneys are hypoxic prior to development of tubulointerstitial fibrosis. (
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