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Figure

Figure 1.  Oncogene activation of the ERK MAPK cascade. Mutationally activated B- B-Raf, Ras and mutationally activated [by missense mutations in the cytoplasmic kinase domain in NSCLC or by extracellular domain truncations (e.g., VIII) in glioblastomas]
Figure 2.  Mammalian MAPK cascades. There are four major mammalian MAPKKK- MAPKKK-MAPKK-MAPK  protein  kinase  cascades
Table 1. Germline mutation of the Ras-Raf-MEK-ERK cascade in human disorders. ProteinMutationsReferences K-Ras1P34R, T58I, V14 I, V152G, D153V(Carta et al., 2006) (Schubbert et al., 2006) H-Ras1G12A, G12C G12E,G12S, G12V, G13C, G13D, K117R, A146T(Aoki et a
Table 2. Small molecule MAPK Inhibitors1. CompanyTargetStatusIndication /Target Population Hoffmann-LaRochep38Phase IIRheumatoid arthritis Hoffmann-LaRochep38Phase IRheumatoid arthritis Pfizerp38Phase IIRheumatoid arthritis AstraZenecap38Phase IRheumatoid
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