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Life Sciences

in Düsseldorf

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Düsseldorf:

Competence in Life Sciences

Düsseldorf is the capital of North Rhine-Westphalia and center of the BioRiver

biotech cluster in the Rhineland. More than 50 life science companies as well

as numerous suppliers and service providers operate in the Düsseldorf region.

Düsseldorf’s Heinrich Heine University is the hothouse of Germany’s biotech industry. Several big players in the chemicals and pharmaceuticals industry, includ-ing Bayer, Henkel, Schwarz Pharma, Degussa and 3M, have their headquarters in the region.

Established Companies and Start-ups

Germany’s most successful biotech companies, such as Qiagen, Rhein Biotech, Evotec or NewLab BioQuality, originate in Düsseldorf. More than 50 life science com-panies have settled here, many of which are Japanese, American or British enterprises.

Düsseldorf is centrally located in Germany and in the heart of Europe.

Life sciences – research for life. This means exploiting advances in biotechnology responsibly in the interest of people, animals and nature at large.

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Research

Düsseldorf ’s Heinrich Heine University is renowned for its strong research capacity. Other important re-search institutions in Düsseldorf include the German Diabetes Research Institute, the Institute for Environ-mental Medical Research and the Biological-Medical Research Center.

Life Science Centers

The Life Science Center Düsseldorf is located next to the university campus and offers space for start-ups and established companies. A second technology center is dedicated to health research and product develop-ment.

Patent Law

When it comes to patent cases, Düsseldorf has Europe’s most important and, after Washington D.C., the world’s second most important patent court. Not surprisingly, therefore, the city is home to a multitude of judges and attorneys specialized in patent law. In addition, the Center for Intellectual Property Law, a compe-tence center for bio patent law, serves as a contact for companies and patent attorneys.

Düsseldorf:

Excellence in Life Sciences

Düsseldorf

Around 20% of the German health market with its hospitals, doctors and pharmacies is concentrated in NRW.

57 institutions of higher education, 27 research institutes, 11 Max Planck Institutes, 14 Fraunhofer Institutes and the Jülich Research Center, one of the largest of its kind in Europe, as well as seven uni-versity clinics and other major clinics are all to be found in NRW, 10 Leibniz Institutes are based in NRW.

With 18 million inhabitants, NRW is both Germany’s most populous federal state (one-fifth of all Germans live here) and Europe’s most densely populated region.

With a gross domestic product of €481 billion (2004), NRW scores higher in international ranking than major European economies such as the Netherlands, Belgium or Sweden.

It is home to 700,000 small and medium-sized companies.

10,000 of the 47,000 German start-ups come from NRW.

39 of Germany’s top 100 companies in terms of revenues are based in NRW.

The Federal State of North Rhine-Westphalia (NRW): Where Life Science Meets Business

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Trade Associations and Organizations

Many important trade associations and other profes-sional organizations of the life sciences and chemicals sectors have their offices in Düsseldorf. The city is home to several regional associations of the chemical industry.

The organization BioRiver – Life Sciences in the Rhineland, which represents the interests of 74 in-stitutions from science and industry from the entire Rhineland, is based in Düsseldorf.www.bioriver.de

Düsseldorf is the seat of LSA Life Science Agency

GmbH, an initiative by the state government of NRW promoting the life sciences.

www.lifescienceagency.de

Other Associations in Düsseldorf

The German Chemical Industry Association (VCI NRW) with 465 member companies and around 130,000 employees.www.vci.de

The German Pharmaceutical Industry Association (BPI) with 60 member companies and around 14,000 employees.www.bpi.de

The Committee of the Employer Associations of the Chemicals Industry of North Rhine-Westphalia (LA) with around 350 companies.www.nrwchemie.de

The Employer Association of Rhineland Chemical

Industry with 200 member companies and around 80,000 employees.www.chemierheinland.de

Life Sciences Network

The communications platform known as

LifeScienceNet Düsseldorf is promoted jointly by the city’s Office for Economic Development, the Cham-ber of Commerce and Industry, and the Life Science Center Düsseldorf. The network provides pragmatic and practical support for science and industry at regional level. It not only holds extremely popular

meetings, but also arranges joint stands at key trade fairs for biotechnology.www. lifescience-dus.de Today more than 50 life science companies operate in the Düsseldorf region.

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Düsseldorf

Red Biotechnology

Bio-Mar GbR • research on active agents for cancer treatment and antibiotics from marine microorganisms

Biotage Europe GmbH • research on active substances

Coley Pharmaceutical GmbH • development of thera-peuticals based on specific immunoreceptors, focus on infectious diseases, cancer, asthma

DeveloGen AutoImmune GmbH • biopharmaceutical R&D, emphasis on metabolic diseases

Dr. Fooke Laboratorien GmbH • immunodiagnostics

Neuraxo Biopharmaceuticals GmbH • development of therapies for the central nervous system

NewLab BioQuality AG • analytical chemistry for quality control, active ingredient research

OrchidBioscience Europe Ltd. • DNA tests

Ortho Biotech • R&D, primarily on cancer and kidney diseases

Orthogen AG • molecular orthopedics

Pharma Waldhof GmbH • nucleotides and nucleosides, bio-chemical products for the pharma and diagnostics industries

Qiagen GmbH• tools for analytical chemistry, diagnostics and production

Rhein Biotech GmbH• biopharmaceuticals, vaccines, research on infectious diseases, product development

Schwarz Pharma AG • pharmaceutical research, focused on the cardiovascular and central nervous system, urology

Serotec GmbH• medical/biotech reagents for R&D

Symetis GmbH • tissue-engineered heart valves

X2 Biotechnologies GmbH

Skin research center

Green Biotechnology

Bayer CropScience AG• agrobiotechnology, active ingredient research

GAMU – Gesellschaft für angewandte Mykologie und Umweltstudien mbH • practical mycology: genetic optimization of useful fungi, production of derivates

Monsanto Agrar Deutschland GmbH • agrobiotechnology

Phytowelt GmbH• plant biotechnology

White Biotechnology

Arysta LifeScience FineChemical Europe GmbH fine chemicals for pharma and other industries

Degussa AG • pharmaceutical amino acids, animal nutrition, components for medical and cosmetic products

Henkel KGaA • biochemistry, bioinformatics, nanobiotech-nology, proteomics

Wako Chemicals GmbH • diagnostic reagents, laboratory and specialty chemicals

X-Zyme GmbH• optimization of enzymes for pharma-ceuticals production

Pharma / Clinical Research / Others

3M Medica • medical and pharmaceutical products

Alphabiocare GmbH • anti-parasite medication, molecular diagnostics

Alpharma-Isis GmbH & Co. KG • generic analgesics, allergy, antibiotics and anti-inflammatory medication

Artes Biotechnology GmbH • development of technology for recombinant production of proteins in yeast and bacteria

Bayer Innovation GmbH • medical technology, security technology

Easyway AG • dietary supplements

FOCUS Clinical Drug Development GmbH research institute for phase I–III clinical studies

HAL ALLERGIE GMBH • specific immunotherapy

Human Genome Sciences Europe GmbH drug development

Inc. Research UK Ltd. • CRO for diseases of the CNS, oncology

Ivax Pharma GmbH • pneumology, contractor for the production of generics

Janssen-Cilag GmbH • pharmaceutical research, mainly der-matology, nephrology, oncology and central nervous system

Labtec Gesellschaft für technologische Forschung und Entwicklung mbH • drug delivery systems, commissioned analytics

Lindopharm GmbH • respiratory therapeuticals, gastroenterology, pain/rheumatism, commissioned services

MCS Micro Carrier Systems GmbH • design and develop-ment of pharmaceutical components

Medifacts International • CRO for cardiovascular, renal, pulmonary and metabolic research

neuraxpharm Arzneimittel GmbH • generic drugs, especially for the CNS

Octapharma GmbH • plasma products

Onkoworks GmbH • therapeuticals and medical products for oncology

PB Pharma GmbH • antiasthmatic medication

Profil Institut für Stoffwechselforschung GmbH clinical studies of metabolic diseases, especially diabetes

R. A. N. Novesia AG Arzneimittel • generic drugs, focus on diabetes, rheumatology, blood pressure, pain, neurology

SIGMA-TAU Arzneimittel GmbH • drugs, mainly for metabolic dysfunctions, oncology, eye/nose/ear medicine

Sanochemia Diagnostics International GmbH diagnos-ticals for radiology

Suppliers and Service Providers

a1-envirotech (TOL measuring instruments, hygrometers), ABI-MED Analysen-Technik GmbH(pipette systems, laboratory devices, thermocyclers, accessories for HPLC and lab automa-tion), Air Liquide Deutschland GmbH, Antek Instruments GmbH, anthos Mikrosysteme GmbH, BBB Biowissenschaft-liche Beratung und Bearbeitung, Beckman Coulter GmbH, behr Labor-Technik GmbH, Capsid GmbH/jobvector.com – the life science career center (job center, recruiting),DCZ Life Science Personalmanagement GmbH, Domnick Hunter GmbH, ensymm company(project management and consult-ing for biotechnology),Eucro GmbH & Co. KG, Fuji Photo Film (Europe) GmbH, Hach Lange GmbH, Hagedorn Medical Services, Healthcare Personalmanagement GmbH, IMECE GmbH (consulting, technology transfer), IVA Analysentechnik e. K., Karsten Rotthowe medizinisch-wissenschaftliche Infor-mationen (information mining, database research), Koch-Glitsch GmbH, Kreienbaum Wissenschaftliche Messsysteme e. K., Bruno Lange GmbH & Co. KG, Concell GmbH, Life Science Center (technology center and incubator, networking, technology transfer, cooperation),Luigs & Neumann Fein-mechanik und Elektrotechnik GmbH, METRISA GmbH, möLab GmbH, Nikon GmbH MIKROSKOPE (microscopes, cameras, image analysis software), Pragmatis GmbH, Reinhard Parthe Wirtschaftsdialog (business consultancy, public rela-tions, coaching, mediation), PS Pharma Service GmbH (con-sulting, logistics, services), Retsch GmbH & Co. KG (particle analysis and sample processing), Science Service Dr. Hempel GmbH, Semadeni (Europe) AG, Systat Software GmbH, Watson-Marlow GmbH (production and delivery of hose pumps), Wiedemeyer Kommunikation GmbH Life Science Companies of Selected Industries in the Düsseldorf Region and their Activities

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Life Science Center Düsseldorf

Düsseldorf ’s Life Science Center (LSC) is right next to the campus of Heinrich Heine University. It was designed as a high-tech center both for well-developed companies and start-ups in the fields of

Biotechnology/genetic engineering

Bioinformatics

Biomedicine

Biopharmaceutics

Medical technology

Nanotechnology

Biomaterials and

Optical technology 1

Düsseldorf ’s Biotech Centers:

Room for Innovative Companies

The Düsseldorf region has two life science centers, which are ideal for

start-ups and established companies alike.

A technology center for start-ups and young compa-nies is located right next to the university campus, and a development center with expertise in health research and product development is just a 10-minute drive away in neighboring Neuss.

The Life Science Center is located right next to the campus of Heinrich Heine University.

Düsseldorf’s Life Science Center offers its tenants state-of-the-art laboratory standards.

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Merowingerplatz 1 a 40225 Düsseldorf Germany Dr. Thomas Heck Phone: +49 (0) 211.602 246 10 Fax: +49 (0) 211.602 246 20 heck@lsc-dus.de www.lsc-dus.de www.bioriverparks.de

Life Science Center:

Contact

Two Buildings – a Perfect Team

The Life Science Center comprises two buildings: the technology center or laboratory building and the office building, which houses service providers from the fields of finance, marketing, law and human resources.

Facilities

Air-conditioned, well-ventilated laboratories

State-of-the-art laboratory standard (up to S2)

High-performance network with CAT 7 data bus

Flexible expansion space

Center Management

A professional center management team organizes events and arranges contacts with local authorities, research networks, companies and university facilities

for the companies in the LSC. In addition, company formation and business consulting, as well as assist-ance with PR and marketing are offered in close coop-eration with Düsseldorf ’s Office for Economic Development.

Area

Total usable floor space approx. 21,000 m2

, compris-ing 12,000 m2laboratory and office and 9,000 m2

office building

Underground parking facility with 360 stalls

Location

The Life Science Center has direct highway connections (A 46, A 57). It takes only 15 minutes to drive to the airport, 10 minutes to Düsseldorf central station and 10 minutes to downtown Düsseldorf.

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Alphabiocare GmbH

Parasite repellents, molecular diagnostics

Arysta LifeScience FineChemical Europe GmbH

Fine chemicals for pharma and other industries

Bayer Innovation GmbH

Medical technology, security technology

BBB (Biowissenschaftliche Bearbeitung und Beratung)

Development and patenting of technologies for molecular biology

Bio-Mar GbR

Research on active agents for can-cer treatment and antibiotics from marine microorganisms

BioRiver – Life Science im Rheinland e. V.

The region’s biotech network

Biotage Europe GmbH

Research on active substances

DCZ Life Science

Personalmanagement GmbH

Human resources for the life sciences

Ensymm company

Project management and consulting for biotech, pharmaceuticals/food processing

Global Sciences GmbH

Technology transfer, medical technology

Healthcare Personalmanagement GmbH

Recruitment services

Human Genome Sciences Europe GmbH

Drug development

IMECE GmbH

Business consultancy, technology transfer

Inc. Research UK Ltd., Düsseldorf office

CRO for diseases of the CNS, oncology

LOYAS Private Finance AG

Financial services

LSA Life Science Agency GmbH

Life science agency of NRW

mediGraft AG

Distribution of biomaterials

Mitsui Chemicals Europe GmbH

Nordrhein-Westfälische Ernährungswirtschaft – Sozial-partnerprojekt e. V.

State initiative against malnutrition

Nippon Gohsei Europe GmbH

Distribution of special plastics for food packaging

Reinhard Parthe Wirtschaftsdialog

Business consultancy, coaching, communication, law, PR

Science Service Dr. Hempel GmbH

Technology transfer, trade show concepts, HR training/development

SULZER Chemtech

Components and services for separation columns and static mixing

univativ GmbH & Co. KG

Consultancy services in IT, Business Administration, Engineering

Düsseldorf University Clinic Neuroimmunology and neurobiology laboratories

Analysis and therapy of neuropathies

X-Zyme GmbH

Optimization of enzymes for pharmaceuticals production

Skin research center

Düsseldorf ’s Biotech Centers:

Room for Young Companies

Companies and Institutions in the Life Science Center Düsseldorf

You will find detailed portraits of the tenants in the Life Science Center on the center’s homepage:

www.lsc-dus.de/unternehmen.htm

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HEALTHCARE Center Neuss

The HEALTHCARE Center Neuss, a mere 10-minute drive from Düsseldorf, focuses on health research and the development of medicines, medical products and diagnostics. It is primarily for companies in the fields of pharmaceuticals, biotechnology, medicine development, medical technology, IT and consulting. The combined laboratory and office space available takes up a total area of 16,000 m2.

The following services are offered at the HEALTH-CARE Center:

FOCUS Clinical Drug Development GmbH: a full-service CRO for phase I to III clinical studies with its own 72-bed clinic and a database with 4,500 testees/1,500 patients. FOCUS services available: phase I to III studies, development consulting, clinical pharmacology, PK/PD, data management, statistics and regulatory affairs

MCS Micro Carrier Systems GmbH: tailor-made

development of pharmaceuticals and medicines

FOCUS Regulatory Affairs Ltd.

Eucro GmbH & Co. KG: product licensing

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The Life Science Center Düsseldorf has direct highway connec-tions (A 46/A 57) and is just a 15-minute drive from the airport and 10 minutes from Düsseldorf central station. Trams and buses stop right outside the entrance.

Düsseldorf’s Biotech Centers

The HEALTHCARE Center in Neuss offers a full-service CRO for phases I to III.

Contact:

HEALTHCARE Center Neuss Ute Balatoni Stresemannallee 6 41460 Neuss Germany Phone: +49 (0) 2131.155 218 Fax: +49 (0) 2131.155 329 info@healthcare-neuss.de www.healthcare-neuss.de

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Faculty of Medicine/University Clinic of interna-tional renown and rich in tradition, with 3,200 students and 1,531 scientific staff members. http://medfak.uniklinikum-duesseldorf.de

Faculty of Economics, Humanities and Law, with a

total of approx. 10,300 students and 351 academic staff members.

www.phil-fak.uni-duesseldorf.de

www.uni-duesseldorf.de/HHU/fakultaeten/wiwi www.jura.uni-duesseldorf.de

Heinrich Heine University:

A Complete Range, Plus Specialty Areas

Heinrich Heine University is a young university – with an almost one-hundred-year-old tradition. The Acad-emy of Practical Medicine, founded in Düsseldorf in 1907, was turned into a university in 1965.

Heinrich Heine University offers a complete range of faculties:

Faculty of Mathematics and Sciences with a strong emphasis on biology, biochemistry, biophysics and pharmacy, with 4,500 students and 591 scientific staff members.www.math-nat-fak.uni-duesseldorf.de

Düsseldorf ’s Heinrich Heine University:

Hothouse of the German Biotech Industry

Düsseldorf’s Heinrich Heine University is Germany’s most successful institution

of higher education in terms of company spin-offs. Businesses that now generate

more than 50 percent of the revenues of all German biotech companies listed on

the stock exchanges. In life science research, it ranks among Germany’s leaders.

The university’s interdisciplinary Biological-Medical Research Center provides a platform for networking medical and fundamental scientific research.

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Scientific Excellence in Life Sciences

With six collaborative research centers on life science, endowed by the German research council DFG, several transregional research centers and five postgraduate programs for the life sciences, Heinrich Heine Uni-versity is among Germany’s leaders in this field. Life science research focuses mainly on molecular aging research in cardiology, hepatology, structural biology and white biotechnology.

Spin-offs from Heinrich Heine University

Qiagen GmbH

Rhein Biotech GmbH

Evotec AG

NewLab BioQuality AG

Neuraxo Biotech GmbH

Orthogen AG

Alphabiocare GmbH

X-Zyme GmbH

Biotecmarin GmbH

Cardion AG

Ensymm company

Kourion Therapeutics GmbH

Research Institutes and Scientific Facilities

The interdisciplinary Biological-Medical Research Center (BMFZ, Biologisch-Medizinisches Forschungs-zentrum) was established to provide a platform for the effective networking of medical and fundamental scientific research. This central scientific facility, which employs 40 scientists, focuses on four fields of research:

Infection biology

Tumor biology

Neurobiology

Cellular communication

www.uni-duesseldorf.de/WWW/BMFZ

The Coordination Center for Clinical Trials (KKS, Koordinierungszentrum für Klinische Studien) also belongs to the university’s Faculty of Medicine.

www.uniklinik-duesseldorf.de/kks

Several university institutes cooperate with the Jülich Research Center.www.fz-juelich.de

Other institutes include:

Institute for Environmental-Medical Research (IUF, Institut für umweltmedizinische Forschung)

www.iuf.uni-duesseldorf.de

German Diabetes Center (DDZ, Deutsches Diabetes-Zentrum) with its three institutes: the German

Heinrich Heine

University:

Contact

Diabetes Clinic (Deutsche Diabetes-Klinik), the Institute for Clinical Biochemistry and the Insti-tute for Biometry and Epidemiology

www.ddz.uni-duesseldorf.de

Center for Intellectual Property Law, a competence center for bio patent law.www.gewrs.de

Research and Technology Transfer

Companies can contact Heinrich Heine University’s Research and Technology Transfer department with questions on third-party funding options and patent exploitation. The department also provides support for the university’s spin-offs.

Heinrich Heine University

Research and Technology Transfer Universitätsstraße 1, building 16.11 40225 Düsseldorf, Germany Director: Anette Traude Phone: +49 (0) 211.811-3508 Fax: +49 (0) 211.811-2422 ftt@verwaltung.uni-duesseldorf.de www.uni-duesseldorf.de/HHU/Forschung

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Professional Training in the Dual System

Germany’s dual system of acquiring professional trai-ning both in school and on the job is held up as an example worldwide. Each year, examinations are held by the Chambers of Commerce and Industry in Aachen, Bonn, Düsseldorf, Cologne and Neuss for (2004):

40 biology laboratory assistants

270 chemical laboratory assistants

85 junior chemical workers

510 chemistry technicians

15 pharmacy technicians

Vocational College Programs

In the BioRiver region, training as biological-technical assistant (BTA), chemical-technical assistant (CTA) or pharmaceutical-technical assistant (PTA) is offered in Düsseldorf, Hilden, Cologne and Aachen. In 2004, the colleges were attended by:

350 BTAs

337 CTAs

91 PTAs

Düsseldorf ’s Advantage:

Highly Qualified Human Resources

One of the most compelling reasons for settling here is the number of

well-trained personnel available. When it comes to placing students into employment,

Düsseldorf ranks second nationwide. Each year, several thousand students

take their final exams in life science-related subjects in NRW.

Every year, several thousand students take their exams in life science-related subjects at 12 universities and six universities of applied sciences in NRW. Five cities in the BioRiver region currently train nearly 1,000 BTAs, CTAs and PTAs, and vocational colleges train several hundred biological-technical and chemical-technical assistants annually.

Universities and Universities of Applied Sciences

The universities and universities of applied sciences in the BioRiver region provide education in biology, bioinformatics, biotechnology, biochemistry, chemis-try, medicine, molecular biology, pharmacy, bioengi-neering, nanotechnology and other sciences.

Each year, examinations are held in the BioRiver region for:

More than 640 biologists and bioengineers

More than 260 chemists and chemical engineers

Around 1,500 physicians

Some 150 pharmacists

Some 15 biochemists/biomedical engineers

1,000 laboratory personnel and several hundred biological-technical, pharmaceutical-technical and chemical-technical assistants are trained in the region each year.

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Universities

University of Technology Aachen

Biology

Biomedical engineering

Biotechnology, molecular biotechnology

Chemistry

Chemical engineering

Medicine

Bielefeld University

Biology

Biochemistry

Bioinformatics and genome research

Chemistry

Genome-based systems biology

Molecular cell biology

Molecular biotechnology

Molecular science / chemistry (course to start in winter term 2007/8)

Systems biology of the brain and behavior

Bochum University

Biology

Biochemistry

Chemistry

Medicine

Bonn University

Biology

Biotechnology

Life science informatics

Medicine

Molecular biomedicine

Molecular biotechnology

Pharmaceutics

Dortmund University

Bioengineering

Chemistry

Chemical engineering

Chemical biology

Heinrich Heine University

Düsseldorf

Biochemistry

Biology

Chemistry

Medicine

Pharmaceutics

Business chemistry

Duisburg-Essen University Duisburg

Chemistry Essen

Chemistry

Medicine

Medical biology

Cologne University

Biology

Bioscience

Chemistry

Medicine

Münster University

Biology

Biotechnology

Bioscience

Chemistry

Medicine

Pharmaceutics

Business chemistry

Paderborn University

Chemistry

Siegen University

Chemistry

University of Witten/Herdecke

Biochemistry

Medicine

Universities of Applied Sciences

University of Applied Sciences Aachen

Applied chemistry (in preparation)

Biotechnology (in preparation)

Chemical engineering

Jülich Department

Bioengineering

Biomedical engineering

Chemical engineering

University of Applied Sciences

Bonn-Rhein-Sieg

Biology

Chemistry

Biomedical sciences

University of Applied Sciences

Gelsenkirchen

Recklinghausen

Chemistry

Molecular biology

University of Applied Sciences

Iserlohn

Nanotechnology and biotechnology

University of Applied Sciences Münster

Biomedical engineering

Chemical engineering

University of Applied Sciences

Niederrhein Krefeld

Applied chemistry

Chemical engineering

Chemistry and biotechnology North Rhine-Westphalia has one of the highest concentrations of

universi-ties in Europe: 20 universiuniversi-ties with life science-related courses are located here (see below).

Human Resources

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The study of inflammation, tumors and infections

Biotechnology www.uni-duesseldorf.de www.fz-juelich.de www.uni-koeln.de www.uni-bonn.de www.rwth-aachen.de

BioRiver Companies: Activities

Around 90 biotech companies have established their headquarters in the BioRiver region, accounting for three quarters of biotech companies in NRW. The out-standing feature of these thriving businesses is their diversity. Their developments cover virtually every field in medicine and range from allergology and asthma through dermatology, infectious diseases and oncology to neurology and veterinary medicine.

Düsseldorf and the BioRiver Region:

Life Science in the Rhineland

With 120 biotechnology companies and 180 service providers and suppliers,

the federal state of North Rhine-Westphalia is one of Germany’s leading

bio-technology locations. Düsseldorf is the hub of this biotech cluster.

The BioRiver region along the Rhine, with its urban centers of Düsseldorf, Cologne, Bonn, Aachen and Jülich, forms the core of North Rhine-Westphalia’s biotechnology landscape. Around three-quarters of the companies in NRW are concentrated here. www.bioriver.de

BioRiver Science:

Rhineland as Research Stronghold

The Rhineland is home to many universities and re-search institutes of international renown, and a uni-que concentration of public and private institutions of higher education and research centers make the Rhineland one of Germany’s top regions for science. The region’s universities focus on:

Neurosciences

Medical engineering and biomaterials

The federal state of North Rhine-Westphalia and the BioRiver region Biotech and technology centers University locations www.bioriver.de/region_bioriver/region_bioriver.php, www.bioriverparks.de

Portrait of the BioRiver Rhine Region

Germany and the location of the federal state of North Rhine-Westphalia with its capital Düsseldorf.

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The technologies include tissue engineering and stem cell therapy as well as bioinformatics and gene expression profiling.

Oligonucleotid synthesis, analysis, process development and the production of pharmaceutical materials in accordance with WHO-GMP are only some of the services offered. The Aachen/Jülich region completes the range with expertise in bioprocess engineering. Enabling technologies are an important field of acti-vity in this region which is home to some of the world market leaders in their respective segment, notably Qiagen, Miltenyi and Amaxa.

Drug-developing companies such as Biofrontera, Coley Pharmaceuticals and Paion – which was listed on the stock exchange at the beginning of 2005 – all have ex-tremely advanced product pipelines. Other compa-nies, Rhein Biotech and Orthogen for example, have already earned market success with their products. Some major players in the German pharmaceuticals and chemicals scene, such as Bayer, Grünenthal, Schwarz Pharma, Madaus, Lanxess, Henkel or Cognis, have established production and research facilities in the BioRiver region, making it one of Europe’s prime

locations for pharmaceuticals and chemicals. www.bioriver.de/region_bioriver/companies.php

BioRiver Parks

All of the region’s 19 technology centers have been integrated into the BioRiver Parks concept. With a total area of 200,000 m2and 70,000 m2office space

they provide the perfect working environment for both start-ups and established companies.

www.bioriverparks.de

Enabling technologies are an important field of activities in this region, which is home to some of the segment’s world market leaders, such as Qiagen, Miltenyi and Amaxa.

Medical research and the fight against disease would be incon-ceivable without the modern methods of biotechnology.

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Company City

A&M Labor GmbH Bergheim

AC Biotech GmbH Jülich

Alphabiocare GmbH Düsseldorf

amaxa GmbH Cologne

Analysis GmbH Cologne

AplaGen GmbH Baesweiler

Artemis Pharmaceuticals GmbH Cologne

Artes Biotechnology GmbH Düsseldorf

Arysta LifeScience FineChemical

Europe GmbH Düsseldorf

Atabis GmbH Cologne

Atto-Tec GmbH Siegen

Axiogenesis AG Cologne

Bayer CropScience AG Langenfeld

Bayer Healthcare Wuppertal

BBT GmbH Baesweiler

BioCell Technologie GmbH Wiehl

Biofrontera Pharmaceuticals AG Leverkusen

Bio-Mar GbR Düsseldorf

Bioreact GmbH Troisdorf

BioSense GbR Bornheim

BioSolveIT GmbH Sankt Augustin

Biotage Europe GmbH Düsseldorf

BioTrend Chemikalien GmbH Cologne

CARO-Biotechnik GmbH Aachen

Celonic GmbH Jülich

CEVEC Pharmaceuticals GmbH Cologne

Chemagen AG Baesweiler

Coley Pharmaceutical GmbH Langenfeld

DAS GIP AG Jülich

Degussa AG Düsseldorf

DeveloGen AutoImmune GmbH Erkrath

Direvo Biotech AG Cologne

Dr. Fooke Laboratorien GmbH Neuss

Easyway AG Monheim

Eurogentec Germany GmbH Cologne

GAMU – Gesellschaft für angewandte Mykologie und Umweltstudien mbH Krefeld

GEN-IAL GmbH Troisdorf

Girindus AG Bensberg

Greentec GmbH Cologne

Grünenthal GmbH Aachen

Hemoteq GmbH Würselen

Henkel KGaA Düsseldorf

HiTec Zang GmbH Herzogenrath

Hölzel Diagnostika GmbH Cologne

IIP Technologies GmbH Bonn

Company City

IMoGen Institut für Molekularpathologie

und Gendiagnostik Bonn

Informium AG Cologne

JFC – Jülich Fine Chemicals GmbH Jülich

Laboratorium Dr. Jung GmbH Cologne

LCL Biokey Gesellschaft für biologisch-medizinische Diagnostik

und Dienstleistung mbH Aachen

LemnaTec GmbH Würselen

MACHEREY-NAGEL GmbH & Co. KG Düren

Madaus Cologne

Matricel GmbH Herzogenrath

MEMOREC Biotech GmbH Cologne

MERLIN Gesellschaft für Bornheim-mikrobiologische Diagnostika mbH Hersel

methesys Cologne

Miltenyi Biotec GmbH Bergisch Gladbach

Monsanto Agrar Deutschland GmbH Düsseldorf

Neuraxo Biopharmaceuticals GmbH Düsseldorf

NewLab BioQuality AG Erkrath

Nexttec GmbH Leverkusen

Operon Biotechnologies GmbH Cologne

OrchidBioscience Europe Ltd. Krefeld

Ortho Biotech Neuss

Orthogen AG Düsseldorf

Paion GmbH Aachen

Pharma Waldhof Düsseldorf

Phytowelt GmbH Nettetal

Qiagen GmbH Hilden

Rhein Biotech GmbH Düsseldorf

Schwarz Pharma AG Monheim

Serotec GmbH Düsseldorf

Sunyx GmbH Cologne

Symetis GmbH Langenfeld

Tropon GmbH Cologne

Verigen AG Leverkusen

Virinova Virus Detection GbR Burscheid

Viscum AG, Niederlassung Bergisch

Bergisch Gladbach Gladbach

VIVA Diagnostika GmbH Cologne

X2 Biotechnologies GmbH Düsseldorf

X-Zyme GmbH Düsseldorf

Wako Chemicals GmbH Neuss

16

17

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Düsseldorf is Germany’s top legal and corporate consulting location.

Düsseldorf is Germany’s second-most important stock exchange and banking location.

Düsseldorf is Germany’s most important fashion center.

Düsseldorf is a leading trade fair venue, hosting more than 22 key trade fairs.

More than 100,000 companies operate in the Düsseldorf region; they include more than 5,000 of foreign origin.

Düsseldorf:

International Business Center

Düsseldorf is the capital of North Rhine-Westphalia, the most densely populated

state in the Federal Republic of Germany. It is also a dynamic and stylish city,

and a leading international business center.

Düsseldorf is centrally located within Europe and offers a concentrated sales potential of 148 million people within a radius of 500 km. Its modern, high-capacity infrastructure and economic diversity would be diffi-cult to find elsewhere.

Economic Diversity

Düsseldorf is Germany’s most important telecommunications location.

Düsseldorf is Germany’s most important advertising location.

Düsseldorf is Germany’s second-most important foreign trade location.

Düsseldorf, a top business location in Germany – where business meets lifestyle.

(18)

Seamless Infrastructure and Quick Access

Air

Flights from Düsseldorf International Airport, which is not far from downtown, serve more than 170 cities worldwide. The most important European business centers, such as London, Paris or Zurich, are less than an hour’s flight away.

Road

Almost 150 million people – 35% of all consumers in the European Union – live within the radius of one day by truck.

Düsseldorf is connected to one of the densest high-way networks in Europe. Amsterdam, Antwerp and Rotterdam, Brussels and Luxembourg are just a two-hour drive away.

Rail

There are more than 300 high-speed

InterCityExpress, InterCity and EuroCity rail links per day to destinations in Germany and other European countries.

The airport is connected with the rail network with around 400 departures per day to the most impor-tant cities in Germany.

International Flair

People in Düsseldorf are cosmopolitan, ensuring that foreign residents always feel welcome:

The International School of Düsseldorf is considered one of the best of its kind in Europe with almost 900 students from more than 41 nations.

The Japanese School is one of the largest outside

Japan with approx. 700 students.

5,000 foreign companies operate here.

For Japan, Düsseldorf is the most important center for activities in Europe, with around 7,000 Japanese citizens and around 450 companies.

Traditionally very well represented in NRW, the USA has 450 companies in the area.

Düsseldorf has just under 40 consulates and almost as many foreign development organizations.

International clubs and international cultural

organizations help people to make contacts.

Quality of Life

Art and culture play an important role in and around Düsseldorf:

Eight opera houses

Three philharmonic and seven symphony orchestras

Five musical and several variety theatres

33 important museums and art collections

11 theatres

Düsseldorf

Düsseldorf – Top Business Location in Germany.

18 19

No. 2 in wholesale foreign trade

Outstanding media location

Dynamic biotech region

Leading fashion location

Top banking center

No. 2 in law firms

No. 1 in management consulting

Leading telecoms center

No. 1 in advertising
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Düsseldorf

and the Rhine-Ruhr region: 11.2 million inhabitants

Greater London: 12.3 million inhabitants

Paris – Ile de France: 10.6 million inhabitants

Greater Chicago: 8.0 million inhabitants

Sports and Recreation

Whether tennis, American football, ice hockey or horse-racing, gliding or surfing, polo or even indoor skiing, every conceivable sports activity can be found here.

Düsseldorf and its delightful surroundings offer

a wealth of leisure and recreational activities. The North Sea can be reached in about two hours.

The region has 60 golf courses.

Living in Düsseldorf

Compared to other German cities, prices for apart-ments and single-family homes are moderate in Düsseldorf.

Comfortable small apartments near the city.

Representative city apartments and condominiums.

Single-family homes.

Superbly furnished mansions in top locations. Düsseldorf offers quality of life.

The Rhine-Ruhr Region Compared with London, Paris and Chicago

(20)

Published by City of Düsseldorf The Lord Mayor Office for Economic Development Burgplatz 1 40213 Düsseldorf Phone: +49 (0) 211. 89-97688 Fax: +49 (0) 211. 89-29062 economic@duesseldorf.de www.duesseldorf.de Concept and copy: Marion Schwartzkopff Editors: Daniel Adler, Marion Schwartzkopff, Philipp Lepper (Editors’ Assistant)

Design and production: doppel. design, Düsseldorf T. Binder

Printed by:

Druckerei Meinke, Neuss Photos: VISUM (p. 1), JOKER (p. 1), Caro (p. 1, 10, 11), Keystone (p. 4), Vario-Press Archiv (p. 6, 9), ddp-Archiv (p. 2, 12, 13, 15), Bildagentur-online (p. 13), Paul Esser, Düsseldorf Translation: Textklinik GmbH Published:

February 2006, 4th revised edition

The publication of this brochure was supported by:

www.jobvector.com www.ensymm.com www.lsc-dus.de www.octapharma.de www.coleypharma.com www.orthogen.com www.innovation.henkel.com www.parthe-wirtschaftsdialog.de www.lsc-dus.de www.nikon-instruments.com www.healthcare-neuss.de www.artes-biotechnology.com www.rheinbiotech.de www.newlab.de www.watson-marlow.de www.degussa.de www.uni-duesseldorf.de www.neuraxo.com www.fooke-labs.de

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