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Cytogenetically normal uterine leiomyomas without MED12-mutations – a source to identify unknown mechanisms of the development of uterine smooth muscle tumors

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Academic year: 2020

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Figure

Table 1 Patients age, size of the tumor, and karyotypeafter classical cytogenetics of five randomly selecteduterine leiomyomas lacking cytogenetically detectablekaryotype alterations as well as MED12-mutation of the“leiomyomas-type” as first described by M
Figure 1 Copy number variation (CNV)-array analysis of two leiomyomas without gross copy number alterations (A: My 678, B: My 706)and one leiomyomas showing multiple genomic losses within five genomic regions (C: My 708) that were absent in the matchingmyometrial tissue (C: myometrium).
Figure 2 Leiomyoma (#708) with extended copy number alterations confined to four distinct chromosomal regions and the wholethe ideogram represent myometrial tissue (light blue) and the leiomyoma (dark blue), respectively
Figure 3 Histologic appearance and cytogenetic analysis of tumor 708–2. Histologic appearance after H&E staining reveals a cell-richleiomyoma with extended hyalinization

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