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Blockade of Toll like receptor 2 prevents spontaneous cytokine release from rheumatoid arthritis ex vivo synovial explant cultures

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Figure

Table 1 Characteristics of RA patients (n = 13)
Figure 1 Pam3CSK4 induced IL-6 and IL-8 in mononuclear cells from RA patientswith TLR2 agonist Pam3CSK4 at 200 ng/ml
Figure 2 TLR2 expression is localized to the perivascular region and lining layer. (A) Two representative photomicrograph (Pt 1 and Pt 2)of RA synovial tissue of 10 patients stained for TLR2 expression
Figure 3 OPN301 significantly inhibited cytokine production in SFMC compared to IgG isotype controlas the mean ± SEM
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