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Novel circulating peptide biomarkers for esophageal squamous cell carcinoma revealed by a magnetic bead-based MALDI-TOF- MS assay

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Figure

Figure 1: Serum peptide fingerprints in the training set. Proteotypic peptides profilings for (healthy controls (green, (A) ESCC (red, n = 100) and (b) n = 98) created by ClinTOF
Table 1: The significantly differentially expressed mass peaks and identified peptides
Figure 2: The ROC curves of the ESCC serum peptide diagnostic model. The ROC curves of (A) the serum peptide diagnostic model (ESCC, n = 201; healthy controls, n = 196), (b) SCC-Ag and Cyfra 21–1 (ESCC, n = 50; healthy control, n = 139), (c) the serum peptide diagnostic model for early stage ESCC and (D) SCC-Ag and Cyfra 21–1 for early stage ESCC.
Figure 3: The identification of ESCC serum peptides. The purified peptides from representative ESCC patients (red line) and healthy controls (green line) using magnetic beads were sequenced by LTQ-Orbitrap-MS/MS
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