A skeletal muscle is composed of a variety of tissues
Slide number: 2
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Muscle Bone
Tendon
Fascia
(covering muscle)
Pg 294
A skeletal muscle is composed of a variety of tissues
Slide number: 3
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Muscle Bone
Tendon
Fascia
(covering muscle) Epimysium Perimysium Endomysium
Fascicles
Fascicle Axon of motor neuron
Blood vessel
A skeletal muscle is composed of a variety of tissues
Slide number: 4
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Muscle Bone
Tendon
Fascia
(covering muscle) Epimysium Perimysium Endomysium
Muscle fibers (cells)
Muscle fiber Sarcolemma
Nucleus Sarcoplasmic reticulum
Fascicles
Fascicle Axon of motor neuron
Blood vessel
A skeletal muscle is composed of a variety of tissues
Slide number: 5
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Muscle Bone
Tendon
Fascia
(covering muscle) Epimysium Perimysium Endomysium
Myofibrils
Myofibril Muscle fibers (cells)
Muscle fiber Sarcolemma
Nucleus Sarcoplasmic reticulum
Fascicles
Fascicle Axon of motor neuron
Blood vessel
A skeletal muscle is composed of a variety of tissues
Slide number: 6
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Muscle Bone
Tendon
Fascia
(covering muscle) Epimysium Perimysium Endomysium
Thick and thin filaments
Filaments Myofibrils
Myofibril Muscle fibers (cells)
Muscle fiber Sarcolemma
Nucleus Sarcoplasmic reticulum
Fascicles
Fascicle Axon of motor neuron
Blood vessel
A skeletal muscle is composed of a variety of tissues
Slide number: 7
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Muscle Bone
Tendon
Fascia
(covering muscle) Epimysium Perimysium Endomysium
Fig. 8.04
Pg. 171
Muscle Fiber
Packet, Pg. 10
Fascicle
Muscle
Fiber
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11. 12.
Skeletal muscle fiber
Slide number: 2
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Skeletal muscle fiber Sarcoplasmic reticulum
Myofibril
B A
Pg. 296
Skeletal muscle fiber
Slide number: 3
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Skeletal muscle fiber Sarcoplasmic reticulum
Myofibril
Z line Z line
Z line
B A
Sarcomere
Skeletal muscle fiber
Slide number: 4
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Sarcomere
Myosin (thick) filaments
Actin (thin) filaments Skeletal muscle fiber
Sarcoplasmic reticulum
Myofibril
Z line Z line
Z line
B A
Skeletal muscle fiber
Slide number: 5
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Sarcomere
Myosin (thick) filaments
Actin (thin) filaments Skeletal muscle fiber
Sarcoplasmic reticulum
Myofibril
Z line Z line
Z line
H zone M line
I band A band I band A band
B A
Fig. 8.03
Pg. 296
H zone
Packet Pg. 12
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11. 12.
H-zone
Pg. 306
Packet Pg. 11
Fig. 8.05
Pg. 298
Neuromuscular
Junction
Packet Pg. 11
Packet Pg. 16
Pg. 297
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11. 12.
Myofibrils
Myofibril Muscle fibers (cells)
Muscle fiber Sarcolemma
Nucleus Sarcoplasmic reticulum
Fascicles
Fascicle Axon of motor neuron
Blood vessel
A skeletal muscle is composed of a variety of tissues
Slide number: 6
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Muscle Bone
Tendon
Fascia
(covering muscle) Epimysium Perimysium Endomysium
Thick filaments
Slide number: 2
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Myosin molecule
Actin molecule
Pg. 296
Thick filaments
Slide number: 3
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Cross-bridges
Troponin Tropomyosin Myosin molecule
Actin molecule
Thick filaments
Slide number: 4
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Myosin filament Actin filament Cross-bridges
Troponin Tropomyosin Myosin molecule
Actin molecule
Sliding filament theory
Slide number: 2
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Tropomyosin Troponin complex Actin monomers
Actin filament
Myosin filament
Ca+2
Muscle contraction
Release of Ca+2 from sarcoplasmic reticulum exposes binding sites on thin filament:
Ca+2 binds to troponin complex Tropomyosin pulled aside Binding sites on
actin filament exposed
1 Exposed binding sites on actin allow the muscle contraction cycle to occur
Ca+2 Ca+2 Ca+2
ADP + P ADP + P
ADP + P ADP + P
Pg. 300
Sliding filament theory
Slide number: 9
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1 Exposed binding sites on actin allow the muscle contraction cycle to occur
Ca+2 Ca+2 Ca+2
ADP + P ADP + P
Contraction cycle
2 Cross-bridge binds actin to myosin
ADP + P ADP + P
P P
ADP ADP
3 ADP + P
Cross-bridge pulls actin filament (power stroke), ADP and P released from myosin
ATP ATP ATP
ATP 4 New ATP binds to myosin, causing linkage to
release
ADP + P ADP + P
5 ATP splits, which provides power to
“cock” the myosin cross-bridge
Sliding filament theory
Slide number: 8
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Ca+2 Ca+2 Ca+2
Ca+2
ATP
Active transport of Ca+2 into sarcoplasmic reticulum, which requires ATP, makes myosin binding sites unavailable.
Muscle relaxation
ADP + P ADP + P
ADP + P ADP + P
When a skeletal muscle contracts
Slide number: 2
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When a skeletal muscle contracts
Slide number: 3
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A band Sacromere
Z line Z line
Actin filaments
Myosin filaments 1 Relaxed
When a skeletal muscle contracts
Slide number: 4
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A band Sacromere
Z line Z line
Actin filaments
Myosin filaments 1 Relaxed
2 Contracting
When a skeletal muscle contracts
Slide number: 5
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A band Sacromere
Z line Z line
Actin filaments
Myosin filaments 1 Relaxed
2 Contracting
3 Fully contracted
Sliding filament theory
Slide number: 1
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Tropomyosin Troponin complex Actin monomers
Actin filament
Myosin filament ADP + P ADP + P
Ca+2 Ca+2 Ca+2
Sliding filament theory
Slide number: 3
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2 Cross-bridge binds actin to myosin ADP + P ADP + P
ADP + P ADP + P
Contraction cycle
P P
ADP ADP
Sliding filament theory
Slide number: 4
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3 Cross-bridge pulls actin filament (power stroke), ADP and P released from myosin
ADP + P
ADP + P ADP + P
Contraction cycle
Contraction cycle
P P
ADP ADP
ATP ATP ATP
Sliding filament theory
Slide number: 5
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ATP 4 New ATP binds to myosin, causing linkage to
release
Sliding filament theory
Slide number: 6
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ATP ATP ATP
5 ATP splits, which provides power to
“cock” the myosin cross-bridge
ADP + P ADP + P
Contraction cycle
Ca+2 Ca+2 Ca+2
Sliding filament theory
Slide number: 7
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ADP + P ADP + P
ADP + P ADP + P
Contraction cycle
Sliding filament theory
Slide number: 10
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Tropomyosin Troponin complex Actin monomers
Actin filament
Myosin filament ADP + P ADP + P
Ca+2
Muscle contraction
Release of Ca+2 from sarcoplasmic reticulum exposes binding sites on thin filament:
Ca+2 binds to troponin complex Tropomyosin pulled aside Binding sites on
actin filament exposed
1
Ca+2 Ca+2 Ca+2
ADP + P ADP + P Ca+2
ATP
Active transport of Ca+2 into sarcoplasmic reticulum, which requires ATP, makes myosin binding sites unavailable.
Muscle relaxation
