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Allele specific RNA interference rescues the long QT syndrome phenotype in human induced pluripotency stem cell cardiomyocytes

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Figure

Figure 1 Long-QT syndrome-type 2 hiPSC cardiomyocytes can recapitulate the disease phenotypecardiomyocytes showed characteristic cardiac muscle striations with cardiac troponin-I staining, and ((( in vitro
Figure 2 KCNH2 mutation c.G1681A causes a hERG-dominant-negative trafficking defect. (hERG (green) in (i) HEK293 and (ii) fibroblast cell lines co-expressing Mut hERG, depicting the dominant-negative phenotype of the mutantform
Figure 3 Design and validation of hERG allele-specific mRNA knockdown. ((e.g. A13). (KCNH2level knockdown (70.5%), without affecting wild-type mRNA
Figure 4 siRNA-mediated knockdown of mutated hERG in long-QT syndrome-type 2 cardiomyocytes
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