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Tumor cell oxidative metabolism as a barrier to PD-1 blockade immunotherapy in melanoma

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Figure

Figure 1. Melanoma cell lines are metabolically heterogeneous and produce various degrees of hypoxia in vivo
Figure 2. Oxidative metabolism in tumor cells promotes increased T cell dysfunction. (ments (right) of PD-1 and Tim-3 expression as in CD4lymph node; TIL, tumor-infiltrating lymphocyte (A) Representative OCR versus ECAR of clone 24 melanoma cells transfect
Figure 3. Inhibiting oxidative metabolism in tumor cells reduces intratumoral hypoxia and increases sensitivity to PD-1 blockade therapy
Figure 4. Oxidative metabolism of tumor cells and hypoxia are associated with decreased antitumor immunity and poor clinical response to PD-1 blockade therapy in patients.tabulated normalized ECAR of isolated tumor cells from melanoma patients that progres
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