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Utility of tolcapone in fluctuating Parkinson's disease

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Figure

Table 1 Pharmacokinetic parameters (mean values) of oral tolcapone (TOL) in healthy volunteers.a TOL was administered alone orin combination with levodopa/benserazide 100 mg/25 mg (L-Dopa/Ben) or levodopa/carbidopa 100 mg/25 mg (L-Dopa/Car)
Figure 1 Reductions in levodopa dosage seen at the end of 3 months weremaintained throughout treatment in the patients who received tolcapone.Copyright © 1997
Table 2 Adverse events associated with tolcapone (at least 5%in a tolcapone dosage group and at least one tolcapone dosagegroup > placebo) (Tasmar PI 2006)

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