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The Crisis of Reproducibility, the Denominator Problem and the Scientific Role of Multi-Scale Modeling

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Figure

Figure 1: Depiction of the Denominator Problem: the relationship between possible behaviors of a biological system (A) with a smaller space of empirical sampling (B) and smaller sets examined by “good” experiments (C1 and C2)
Figure 2: Role of MSMs in determining what is similar
Figure 3: Depiction of the ability of MSMs to more completely address the Denominator Problem

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