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A hypothesis linking low folate intake to neural tube defects due to failure of post translation methylations of the cytoskeleton

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Figure

Fig. 1. The structural and enzymatic relationships between methion-ine, homocysteine and cysteine and the cofactors involved
Fig. 3. Embryonic metabolic pathways affecting SAM/SAH levels.
Fig. 4. The apical end of a single ectoderm cell with three cytoskel-etal elements forming the bistable organelle, the cell state splitter.times larger than the horizontal scale
Fig. 5. Schematic of the nuclear state splitter. Schematic of thesion of microtubules is accomplished by polymerization

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