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Inhibitory activity of 9 phenylcyclohepta[d]pyrimidinedione derivatives against different strains of HIV 1 as non nucleoside reverse transcriptase inhibitors

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Figure

Figure 1 The structural formulas of TNK651 and PCP derivatives. (a)TNK-651, (b)1-[(benzyloxy) methyl]-9-phenyl-cyclohepta[d]pyrimidinedione (BmPCP), (c) 1-Allyl -9-phenyl-cyclohepta[d ]pyrimidinedione(APCP), (d)1-Benzyl -9-phenyl-cyclohepta[d]pyrimidinedione(BPCP),(e)1-(Ethoxymethyl)- 9-phenyl-cyclohepta[d]pyrimidinedione (EPCP)
Table 1 The inhibitory activity of PCPs on infection byHIV-1 SF33
Figure 2 Time-of-addition assay of compoundsinfection. Results are the mean inhibition rate in duplicateT-20(

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