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(1)

1.

What is the function of:

Cone cells?

Rod cells?

2.

The perceived pitch of a sound is

dependent on… ?

3.

What is the difference between

(2)

1.

What is the function of:

Cone cells?

Color

Rod cells?

Light

2.

The perceived pitch of a sound is

dependent on… ?

wavelength (

λ

)

1.

What is the difference between

(3)

Chapter 50

(4)

The location and function of several

types of sensory receptors

How skeletal muscles contract

Cellular events that lead to muscle

(5)

Mechanoreceptors

: physical stimuli –

pressure, touch, stretch, motion, sound

Thermoreceptors

: detect heat/cold

Chemoreceptors

: transmit solute conc.

info – taste (gustatory), smell (olfactory)

Electromagnetic receptors

: detect EM

energy – light (photoreceptors),

electricity, magnetism

Pain receptors

: respond to excess heat,

(6)

This rattlesnake and other pit vipers have a pair of infrared receptors, one between each eye and nostril. The organs are sensitive enough to detect the infrared radiation emitted by a warm mouse a meter away.

Eye Infrared receptor

Some migrating animals, such as these beluga whales, apparently sense Earth’s magnetic field and use the information, along with other cues, for orientation.

(7)

Reception

Reception

: receptor detects a

stimulus

Sensation = action potentials reach

Sensation

brain via sensory neurons

Perception

Perception

: information processed

(8)

Outer ear Middleear Inner ear Pinna Auditory canal Tympanic membrane Eustachian tube Middle ear Stapes Incus Malleus Skull bones Semicircular canals Auditory nerve, to brain Tympanic membrane Oval window Round window Cochlea Eustachian tube Auditory nerve Tympanic canal Cochlea duct

Organ of Corti Vestibular canal Bone To auditory nerve Axons of sensory neurons Basilar membrane Hair cells Tectorial membrane

(9)

Semicircular canals

Flow

of endolymph

Vestibular nerve

Nerve fibers Vestibule

Utricle Saccule

Ampulla

Flow

of endolymph

Cupula

Body movement

Hairs Hair cell

(10)

Cornea

Ciliary body

Suspensory

ligament

Iris

Pupil

Aqueous

humor

Lens

Vitreous humor

Central artery and

vein of the retina

Optic disk

(blind spot)

Fovea (center

of visual field)

Optic

nerve

Retina

Choroid

Sclera

(11)

Compound eyes

: several

thousand ommatidia (light

detectors) with its own

lens;

insects & crustaceans

Vertebrates:

Rods

: sense light

Cones

: color vision

Rhodopsin

:

light-absorbing pigment that

triggers signal transduction

pathway that leads to sight

Retina Optic nerve To brain Cone Photoreceptors Retina Rod Neurons Pigmented epithelium Bipolar cell Amacrine cell Horizontal cell Optic nerve

(12)

Hydrostatic

: fluid held under

pressure in closed body compartment

Hydra, nematodes, annelids

Exoskeletons

: hard encasements on

surface of animal

Insects, mollusks, crustaceans

Endoskeleton

: hard supporting

elements buried within soft tissues

(13)

Shoulder girdle Scapula Clavicle Sternum Skull Appendicular skeleton Axial skeleton Key Rib Humerus Vertebra Radius Examples of joints Fibula Ulna Tibia Pelvic girdle Carpals Phalanges Metacarpals Femur Patella Tarsals Metatarsals Phalanges Ulna

Pivot joints allow us to rotate our forearm at the elbow and to move our head from side to side. Ulna

Hinge joints, such as between the humerus and the head of the ulna, restrict movement to a single plane.

Humerus

Ball-and-socket joints, where the humerus contacts the shoulder girdle and where the femur contacts the pelvic girdle, enable us to rotate our arms and legs and move them in several planes. Head of

humerus Scapula

(14)

Biceps

contracts

Human

Triceps

relaxes

Forearm

flexes

Biceps

relaxes

Triceps

contracts

Forearm

extends

Extensor

muscle

relaxes

Flexor

muscle

contracts

Grasshopper

Extensor

muscle

contracts

Flexor

muscle

relaxes

Tibia

extends

Tibia

flexes

Muscles always

contract

Muscles work in

antagonistic pairs

(15)

Bundle of muscle fibers Single muscle fiber (cell) Plasma membrane Nuclei Muscle Myofibril Dark band Sarcomere Z line Light band I band TEM

A band I band0.5 µm M line

Thick filaments (myosin)

SarcomereH zone Z line

Thin filaments (actin)

Z line

Attached to bones by

tendons

Types of muscle:

smooth

(internal organs)

cardiac

(heart)

Skeletal

(striated)

1 long fiber = single muscle

cell

Each muscle fiber = bundle

of

myofibrils

, composed of:

Actin: thin filaments

(16)

Sarcomere

0.5 µm

Z

H

A

Relaxed muscle fiber

I

Contracting muscle fiber

Fully contracted muscle fiber

Z lines

– border

I band

– thin actin filaments

(17)

Sarcomere

0.5 µm

Z

H

A

Relaxed muscle fiber

I

Contracting muscle fiber

Fully contracted muscle fiber

1.

Sarcomere relaxed: actin &

myosin overlap

2.

Contracting:

Muscle fiber stimulated by

motor neuron

motor neuron

Length of sarcomere is reduced

Actin slides over myosin

3.

Fully contracted: actin & myosin

completely overlap

Sliding-filament model

: thick &

thin filaments slide past each

other to increase overlap

(18)

Ca2+ released

from sarcoplasmic reticulum

Mitochondrion Motor

neuron axon

Synaptic terminal

T tubule

Sarcoplasmic reticulum

Myofibril

Plasma membrane of muscle fiber

(19)

Ca2+

CYTOSOL Ca2+

SR

PLASMA MEMBRANE T TUBULE

Synaptic cleft Synaptic terminal of motor neuron

(20)

Myosin-binding sites blocked.

Myosin-binding sites exposed.

Tropomyosin

Ca

2+

-binding sites

Actin

Troponin complex

Myosin-binding site

(21)

Thin filaments

Thick filament

Thin filament

Thick filament Myosin head (low-energy configuration)

Cross-bridge binding site

Myosin head (high-energy configuration) Actin

Cross-bridge Myosin head

(low-energy configuration) Thin filament moves

toward center of sacomere.

Hydrolysis of ATP

Hydrolysis of ATP

by myosin

by myosin

cross-bridge formed

cross-bridge formed

thin

thin

filament pulled toward center of sarcomere

(22)

Speed of muscle contraction:

Speed of muscle contraction:

•Fast fibers – brief, rapid, powerful contractions

•Slow fibers – sustain long contractions (posture)

(23)

ALS (Lou Gehrig’s disease)

: degeneration

of motor neurons, muscle fibers atrophy

Botulism

: block release of acetylcholine,

paralyzes muscles

Myasthenia gravis

: autoimmune disorder,

produce antibodies to acetylcholine

Calcium deficiency

: muscle spasms and

cramps

Rigor mortis (after death)

: no ATP to

break actin/myosin bonds; sustained muscle

contraction until breakdown (decomposition)

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