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Original Article CXCR4 enhances invasion and proliferation of bone marrow stem cells via PI3K/AKT/NF-κB signaling pathway

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Academic year: 2020

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Figure

Figure 1. The construction of CXCR4 overexpressed MSCs. A. The detection of CXCR4 expression in MSCs and CXCR4 overexpressed MSCs by RT-PCR
Figure 3. The expression of MMP20, MMP9, MMP2, MMP13, MMP7, MMP10, MMP8, MMP1, TIMP1, TIMP2, TIMP3 and TIMP4 in MSCs, CXCR4 overexpressed MSCs, SPION labeled MSCs, CXCR4 overexpressed SPION labeled MSCs.
Figure 5. CXCR4 regulates MSCs migration via PI3K/AKT/NF-κB signaling. A, C. Transwell assay showed the migra-tion behavior of MSCs, CXCR4 overexpressed MSCs, CXCR4 overexpressed MSCs treated with LY294002, CXCR4 overexpressed MSCs treated with PDTC
Figure 6. The expression of MMP9 and MMP2 in MSCs, CXCR4 overexpressed MSCs, CXCR4 overex-pressed MSCs treated with LY294002, CXCR4 over-expressed MSCs treated with PDTC.

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