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COTI-2, a novel small molecule that is active against multiple human cancer cell lines in vitro and in vivo

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Academic year: 2020

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Figure 1: A. COTI-2, a third generation thiosemicarbazone, was designed using the CHEMSAS computational platform
Figure 2: COTI-2 is significantly more effective than cetuximab or erlotinib in inhibiting colorectal cancer cell line proliferation
Figure 3: Human glioblastoma cell lines are sensitive to COTI-2 treatment. A. Human glioblastoma cell lines (U87-MG, SNB-19, SF-268, and SF-295) were cultured with varying concentrations of COTI-2
Figure 4: COTI-2 induces apoptosis in human cancer cells. A. SHP-77 SCLC cells were treated with varying concentrations of COTI-2 for 48 h then stained with Annexin V and 7AAD to measure early and late apoptotic events
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