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KH176 under development for rare mitochondrial disease: a first in man randomized controlled clinical trial in healthy male volunteers

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Figure

Fig. 1 Study design. a. SAD study. D = Dose; SD = Single dose; FU = follow-up. * Each dose was followed by an interim safety and 24-h PK evaluation,which determined the dose selection for the next dose
Table 1 Summary of demographic characteristics for subjects included in the SAD and MAD study
Fig. 2 Mean plasma concentrations of KH176 and its metabolite KH176m after single and multiple dose administration to healthy subjects.Plasma-concentration/time curve of KH176 for the SAD study (fasted state).c a
Table 2 Summary of plasma pharmacokinetic variables of KH176
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