Advances in Biology and Treatment of Malignant Brain Gliomas

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Advances in Biology and Treatment of Malignant Brain Gliomas

International Congress – 2

nd

Edition

Rome, June 12-13, 2014

President

Giulio Maira

Vice Presidents

Ruggero De Maria, Antonio Iavarone, Angelo Vescovi

Scientific Committee

Giulio Maira

Angelo Vescovi

Ruggero De Maria

Antonio Iavarone

Riccardo Riccardi

Roberto Pallini

Q. Giorgio D’Alessandris

Congress Venue:

Sala del Tempio di Adriano – Piazza di Pietra – Roma

Congress Registration Fares

Senior Early registration (deadline April 30, 2014): € 300. Late registration: € 400 Junior (Students, Residents, Fellows) Early registration (deadline April 30, 2014): € 80. Late registration: € 120

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Congress opening Authorities Welcome

MORNING SESSION: GENETICS AND BIOLOGY OF MALIGNANT GLIOMAS

Chair: Antonio Iavarone (New York, NY), Giovanni Neri (Roma, Italy)

8:30 – 8:50 Cancer Genetics of Malignant Glioma Webster K. Cavenee (San Diego, CA) 8:50 – 9:10 Drivers of Oncogenesis and Master Regulators of Malignant Glioma Antonio

Iavarone (New York, NY)

9:10 – 9:30 Biomarkers for Malignant Astrocytic Tumors Kenneth D. Aldape (Houston, TX) 9:30 – 10:00 Discussion

10:00 – 10:30 Coffee break

Chair: Ruggero De Maria (Roma, Italy), Angelo Vescovi (Milan, Italy)

10:30 – 10:50 Glioblastoma Microenviroment and Brain Invasion Jeremy N. Rich (Cleveland,

OH)

10:50 – 11:10 Extracellular Vesicles in Glioblastoma: Saboteurs, Biomarkers and Therapeutic Agents Xandra O. Breakefield (Charlestown, MA)

11:10 – 11:30 Brain Tumor Stem Cells Angelo Vescovi (Milan, Italy)

11:30 – 11:50 Biomolecular Characterization of Peritumor Tissue Gigliola Sica (Roma, Italy) 11:50 – 12:20 Discussion

12:20 – 12:25 Introduction to Lecture Giulio Maira (Roma, Italy)

12:25 – 13:00 Lecture: Angiogenesis in Glioblastoma Napoleone Ferrara (San Diego, CA)

13:00 – 14:30 Lunch

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June 12, 2014

AFTERNOON SESSION: PEDIATRIC BRAIN TUMORS

Genetics and biology

Chair: Anna Lasorella (New York, NY), Riccardo Riccardi (Roma, Italy)

14:30 – 14:50 Update in Genetics and Biology of Medulloblastoma and Ependymoma Michael D.

Taylor (Toronto, Canada)

14:50 – 15:10 Update in Genetics and Biology of Pediatric Glioma Nada Jabado (Montreal,

Canada)

15:10 – 15:30 Stem Cells and Pediatric Tumors Anna Lasorella (New York, NY) 15:30 – 16:00 Discussion

16:00 – 16:30 Coffee break

New therapies in pediatric brain tumors

Chair: Alberto Broniscer (Memphis, TN), Antonio Iavarone (New York, NY)

16:30 – 16:50 Pathology of Pediatric Brain Tumors Felice Giangaspero (Roma, Italy)

16:50 – 17:10 New Approaches in the Treatment of Diffuse Intrinsic Pontine Gliomas in Children

Alberto Broniscer (Memphis, TN)

17:10 – 17:30 Future Perspectives in Treatment of Pediatric High Grade Gliomas Iacopo Sardi

(Firenze, Italy)

17:30 – 17:50 Visual improvement with Nerve Growth Factor in Patients with Optic Pathway Gliomas Riccardo Riccardi (Roma, Italy)

17:50 – 18:20 Discussion

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MORNING SESSION 1: SIGNALING PATHWAYS AND MOLECULAR TARGETS FOR MALIGNANT GLIOMA

Chair: Alba A. Brandes (Bologna, Italy), Riccardo Soffietti (Turin, Italy)

8:00 – 8:20 Clinical trials in Low Grade Gliomas: from Chemotherapy to Target Therapies

Roberta Rudà (Turin, Italy)

8:20 – 8:40 New Clinical Trials in GBM Gaetano Finocchiaro (Milan, Italy)

8:40 – 9:00 Growth Factors and Tyrosine Kinase Receptors Inhibitors Mark R. Gilbert

(Houston, TX)

9:00 – 9:20 Immunotherapy approaches for Glioblastoma Linda Liau (Los Angeles, CA) 9:20 – 9:40 Ephrin Receptor Inhibition in Glioblastoma Elena Binda (Milano, Italy) 9:40 – 10:00 Targeting Brain Tumor Stem Cells Ruggero De Maria (Roma, Italy) 10:00 – 10:30 Discussion

10:30 – 11:00 Coffee break

11:00 – 11:05 Introduction to Lecture Ruggero De Maria (Roma, Italy)

11:05 – 11:40 Lecture: Towards a Personalized, Tailored Therapy for Gliomas Monika Hegi

(Lausanne, Switzerland)

MORNING SESSION 2: DIAGNOSTIC APPROACHES FOR GLIOMAS

Chair: Alessandro Bozzao (Roma, Italy), Roberto Floris (Roma, Italy)

11:40 – 12:00 Overview of Imaging Techniques for Diagnosis of Brain Tumors Cesare Colosimo

(Roma, Italy)

12:00 – 12:20 Role of Imaging in Follow-up of Malignant Gliomas Roland Wiest (Bern,

Switzerland)

12:20 – 12:40 Imaging Biomarkers in Neuro-Oncology Whitney Pope (Los Angeles, CA)

12:40 – 13:00 Intraoperative Contrast Enhanced Ultra-sound (CEUS) for Brain Tumor Surgery

Francesco DiMeco (Milan, Italy)

13:00 – 13:30 Discussion

13:30 – 14:30 Lunch

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June 13, 2014

AFTERNOON SESSION: SURGERY FOR BRAIN TUMORS

Overview session

Chair: Carmine Carapella (Roma, Italy), Roberto Delfini (Roma, Italy)

14:30 – 14:50 Surgery for Low-Grade Gliomas Francesco Tomasello (Messina, Italy) 14:50 – 15:10 Surgery for High-Grade Gliomas Giulio Maira (Rome, Italy)

15:10 – 15:30 “Supratotal” Resection for diffuse low-grade gliomas Hugues Duffau (Montpellier,

France)

15:30 – 15:50 Awake Surgery in Glioma Patients Lorenzo Bello (Milan, Italy) 15:50 – 16:20 Discussion

16:20 – 16:50 Coffee break

New perspectives

Chair: Linda Liau (Los Angeles, CA), Vincenzo Valentini (Roma, Italy)

16:50 – 17:05 Intaraoperative imaging (iMRI and iCT) in the treatment of Gliomas: The Johns Hopkins experience Alessandro Olivi (Baltimore, MD)

17:05 – 17:20 Fluorescence-guided resections of malignant gliomas - an update Walter Stummer

(Munster, Germany)

17:20 – 17:35 Intraoperative implant of Chemotherapy-releasing Devices Massimo Scerrati

(Ancona, Italy)

17:35 – 17:50 Long-term Results of Radioimmunotherapy in the Treatment of Malignant Gliomas

Hans-Jürgen Reulen (Munich, Germany)

17:50 – 18:05 Proton beam and Carbon Ion Therapy in the Treatment of Malignant Gliomas

Figure

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