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TLR8 deficiency leads to autoimmunity in mice

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Figure

Figure 1Targeted disruption of the mouse
Figure 2Enhanced responses to TLR7 ligands by Tlr8–/– DCs. (A) BMDCs from WT and Tlr8–/– mice were stimulated with the indicated amounts of R848, polyA:U, CpG, polyI:C, and LPS
Figure 3Increased TLR7 expression and NF-κB activation in Tlr8–/– BMDCs. WT and Tlr8–/– BMDCs were left untreated or stimulated with 50 nM (A and B) or 100 nM (C and H) R848 for the indicated times
Figure 4Defect of MZ B cells in Tlr8–/– mice. (A) Spleen weight and size of 8-week-old male WT and Tlr8–/– mice
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