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Metabolic remodeling during the loss and acquisition of pluripotency

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Figure

Fig. 1. Overview of cellular metabolism. The major cellular metabolicpathways (indicated in red): glycolysis, pentose phosphate pathway,β-oxidation, TCA cycle and oxidative phosphorylation (OxPHOS)
Fig. 2. Dynamic changes in pluripotency in vivo and in vitro. (A) Pluripotent cells emerge from the inner cell mass (ICM) of the early blastocyst
Fig. 3. Metabolic and transcriptional changesduring entry into and exit from pluripotency.(A) A metabolic switch from mitochondrial oxidativephosphorylation to glycolysis takes place earlyduring the acquisition of human pluripotency
Fig. 4. Metabolite levels influence the epigenetic landscape of ESCs. Cytoplasmic acetyl-CoA acetylates histones via histone acetyltransferase (HAT)activation
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