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IL 33 and ST2 comprise a critical biomechanically induced and cardioprotective signaling system

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Figure

Figure 1IL-33 is induced by mechanical strain in cardiac fibroblasts. (A and B) Quantitative analyses of gene expression of IL-33 by quantitative PCR (A) and sST2 by Northern analysis (B) in rat neonatal cardiomyocytes (white bars) and fibroblasts (black b
Figure 2IL-33 blocks prohypertrophic stimuli in cardiomyocytes and sST2 inhibits IL-33.
Figure 3IL-33 transiently activates NF-
Figure 4IL-33/ST2 signaling is cardioprotective in vivo. (A) Representative H&E and Sirius red stains and (B) quantitative analyses of samples from each group
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