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Succinate is an inflammatory signal that induces IL 1 beta through HIF 1 alpha

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Figure

Fig. 1. Glycolysis is necessary for LPS-induced IL-1βPBS for 3h, then 15 mg/kg LPS or PBS for 1.5h
Fig. 2. HIF-1αReporter activity in RAW-264 cells transfected with il1b- or −357 il1b. Representative of 3experiments
Fig. 3. Succinate is induced by LPS to drive HIF-1α(A) Glucose utilization over time, as a ratio of ECAR:OCR in LPS-treated BMDMs,analysed on the Seahorse XF-24
Fig. 4. Glutamine is the source of LPS-induced succinate(A) SLC3A2 mRNA in LPS-treated BMDMs for 8 and 24h

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