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Sparse conserved under methylated CpGs are associated with high order chromatin structure

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Academic year: 2020

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Figure

Fig. 1 Identification of scUMC. a Number of sample methylomes sharing either a given UMR (no less than four CpG, right) or a given UMC in anotherwise discarded UMR (less than four CpG, left)
Fig. 2 Features of scUMCs.(non-conserved UMCs). a–d Three groups of under-methylated features are color-coded: blue (conserved UMRs), red (scUMCs), and gray a CpG density (normalized to 100 bp)
Fig. 3 scUMCs are enriched in chromatin interactions. a, b scUMC (a) and conserved UMR (b) enrichment for 161 transcription factors (TF); thex-axes represent the log2 ratio of observed vs
Fig. 4 Cell lineage scUMCs are associated with the dynamic regulation of chromatin loops.Rad21, Znf143, CTCF in GM12878 and H1 cells
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