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Dose dependent roles for canonical Wnt signalling in de novo crypt formation and cell cycle properties of the colonic epithelium

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Figure

Fig. 1. Upregulation of canonical Wnt target genesin the proliferative compartments of colonic crypts.
Fig. 2. β-Catenin induction leads to de novowith increased expression of ISC markers in the colon
Fig. 3. Slow cycling properties of β-catenin-induced colonic cells. (A) Doubleimmunostaining for β-catenin (green) and Ki-67
Fig. 4. Notch activation contributes to the maintenance of a slow-cycling state in β-catenin-induced colon
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