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Structure–activity Relationships of Amyloid Beta aggregation Inhibitors Based on Curcumin: Influence of Linker Length and Flexibility

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Figure

Figure 1: The structural components of natural amyloid betapounds. (B) The structural elements common to curcumin-like amy-loid ligands
Table 1: Structure–activity relationships library: compounds tested for inhibition of amyloid beta aggregation
Figure 2: Synthesis of curcumin mimetics. (A) Addition of acetophenone to vanillin (1) in basic conditions afforded the aldol condensationproduct (6)
Figure 3: Hydroxy substitutions on the aromatic end groups are required for inhibition
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