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Gefitinib resistance resulted from STAT3-mediated Akt activation in lung cancer cells

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Figure

Figure 1: Gefitinib treatment on Akt inhibition and recovery. (A) Westernblotting analysis shows that gefitinib inhibits multiple protein regulators involved in EGFR signaling pathway and induces Akt recovery in A549 cells (human lung cancer cell line)
Figure 3: Gefitinib inhibits EGFR phosphorylation but induces STAT3 activation in lung caner cells
Figure 6: STAT3 inhibitor enhances the inhibitory effect of gefitinib on cell growth. CyQUANT NF Cell Viability Assay Kit (Invitrogen) was used to stain viable cells

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