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Amino acid dependent cMyc expression is essential for NK cell metabolic and functional responses in mice

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Academic year: 2020

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Figure

Fig. 1 cMyc is required for IL-2/IL-12-induced NK cell metabolism.analysis was performed using a two-way ANOVA with Tukey post test (***Flow cytometry analysis of mitochondrial mass using MitoTracker Red (MT Red) staining
Fig. 2 cMyc, but not HIF1left unstimulated or were stimulated for 18 h with IL-2/IL-12 beforeData are mean ± s.e.m
Fig. 3 mTORC1, but not Akt, is required for cMyc expression in IL-2/IL-12-a theoretical value of 1 (analysis was performed using Student'sstimulated NK cells
Fig. 4 SLC7A5 activity is required for IL-2/IL-12-induced cMyc expression.Tukey post test (0.005, ns non-signiqPCR analysis ofIL-2/IL-12 in the presence or absence of leucine for 18 h before immunoblotanalysis of cMyc, pS6 and Akt.leucine or the addition o
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