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Hgf/Met activation mediates resistance to BRAF inhibition in murine anaplastic thyroid cancers

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Figure

Figure 1. BRAFV600Eexpression of rtTA is achieved by crosses with arrow) and spindle-shaped cells (single arrow)
Figure 2. BRAFV600Eing an ATC (left), then regression 3 weeks after dox withdrawal (middle), and a recurrence 7 weeks later (right)
Figure 3. Reactivation of the MAPK pathway drives tumor recurrences. (licate. Bars represent the ICA) MAPK output score for normal mouse thyroid, BRAF-PTCs (from TPO-Cre/LSL-BrafV600E mice) (31), BRAF/p53 ATCs, and recurrent tumors was calculated from expr
Figure 4. Met amplification and Hgf overexpression in recurrent tumors. (A) IGV of copy number changes determined by FACET from exome sequencing reads of recurrent ATCs
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