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Central airways remodeling in COPD patients

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Figure

Table 1 Patients’ characteristics and spirometry indices
Figure 1 Immunohistochemical staining for collagen I, versican, and decorin in airway biopsies of control subjects (A–C), and in COPD patients (D–F).Note: In the biopsy specimens from COPD patients, collagen I, versican, and decorin were prominent within the subepithelial layer.Abbreviation: COPD, chronic obstructive pulmonary disease.
Figure 3 area of positive staining for α-sMa standardized for basement membrane squared (a/Pbm2) in the biopsy specimens from CTr and COPD subjects.Note: Data are presented as mean ± se.Abbreviations: α-sMa, alpha-smooth muscle actin; CTr, control; COPD, chronic obstructive pulmonary disease; se, standard error.
Figure 4 Correlation between spirometric indices and the area of collagen positive staining in the subepithelial area standardized for total subepithelial area (a/Tot a) in control, and COPD subjects.Note: There is an inverse correlation between obstructive spirometric indices and subepithelial collagen deposition.Abbreviations: COPD, chronic obstructive pulmonary disease; FeV1, forced expiratory volume in the first second; % pred, % predicted; FVC, forced vital capacity.

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