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Naltrexone sustained-release/bupropion sustained-release for the management of obesity: review of the data to date

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Figure

Table 1 Antiobesity drugs in development
Figure 1 Central and peripheral mechanisms of appetite and satiety and site of action of bupropion and naltrexone.Abbreviations: α-MSH, α-melanocyte-stimulating hormone; AgRP, Agouti-related protein; β-eND, β-endorphin; BUP, bupropion; CART, cocaine and amphetamine-regulated transcript; CCK, cholecystokinin; CNS, central nervous system; GLP-1, glucagon-like peptide-1; NAL, naltrexone; NPY, neuropeptide Y; POMC, pro-opiomelanocortin; PP, pancreatic polypeptide; PYY, peptide YY.
Table 2 Major clinical trials assessing bupropion plus naltrexone as obesity treatment

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