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Nucleotide excision repair in aging & cancer

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Figure

Table  1.   Overview  of  most  abundant  XP  features,  including  average  age  of  onset  or  frequency  of  the  specific  feature in patients overall (indicated by %)    3.2  p53 in DNA repair and cell cycle arrest   p53 is the most mutated gene found
Figure 2. Hprt mutant frequencies including standard deviations of Xpc‐/‐, Xpc+/‐ and wild type controls at an age  of 13 and 52 weeks in spleen. The numbers of biological replicas are between 4 and 10. For further details see  Materials and Methods sectio
Figure 4. Survival of mouse embryonic fibroblasts including standard deviations of Xpc ‐/‐ , Xpa ‐/‐  and their wild type  controls under different levels of oxygen pressure. Cells at the first passage were all cultured at 3% oxygen (A); 
Figure  2.  Survival  curves  of  wild  type  and  Xpc*p53  male  (A)  and  female  (B)  mice  after  short‐term  carcinogen  exposure.  Mice  of  8‐10  weeks  old  were  exposed  to  genotoxic  (2‐AAF,  Phe)  and  non‐genotoxic  (CsA,  DES,  WY,  DEHP) ca
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