Lugano Stem Cell Meeting. Cardiocentro Ticino Lugano Switzerland

(1)

P R E L I M I N A R Y P R O G R A M

Lugano

Stem Cell

Meeting

1

st

_-2

nd

_July

2008

Cardiocentro Ticino

Lugano

Switzerland

UNDER THE PATRONAGE OF



(2)

In this first edition of the Lugano Stem Cell Meeting we

would like to offer the opportunity to interact with the

most important key opinion-leaders on stem cells.

The first day focuses on GMP regulation of stem cell

therapies and process manufacturing by listening to

people directly involved in this field. Stem cell biology

and regenerative medicine will also be widely discussed

during the meeting.

The second day is dedicated to the latest benchmarking

and some ongoing clinical trials focusing on cellular

therapy after acute STEMI and in chronic ischemic

diseases.

The meeting concludes with a discussion regarding

present controversies and future challenges. Excellent

talks and live cases from our cath-lab will improve the

knowledge of these exciting topics.

SCM can be followed entirely (from Tuesday 1

st

_{July 9:50}

a.m. to Wednesday 2

nd

_{July 3:15 p.m.) or one day only.}

On 2

nd

_{July at 2:00 p.m. will start MTE 2008, 5}

th

Interventional Symposium on High Risk Coronary

Intervention (common part until 3:15 p.m.). Please

clearly tick in the registration form the sessions you

will attend.

We look forward to welcoming you in Lugano.

With best regards

Giuseppe Astori, Tiziano Moccetti,

Gianni Soldati, Daniel Sürder

Learning objectives

• Update on current EU regulation on human cell-based medicinal products • GMP translation of cell processing • Critical discussions over the most

de-bated topics of regenerative medicine • Knowledge on ongoing clinical trials in

patients after STEMI and with chronic ischemic diseases

• Understand and face current contro-versies and learn more about defining the optimal patient that could profit from cellular therapy

Targeted audience • Biologists • Biotechnologists

• People involved in GMP processing (QA, QC, RA) • Cardiologists • Internists • General practitioners

Lugano

Stem Cell

Meeting

(3)

P R E L I M I N A R Y P R O G R A M T U E S D A Y 1S T_{J U L Y 2 0 0 8}

S TEM CELL S FROM THE BENCHTOP TO THE CLINIC

09:20 – 09:50 Registration

09:50 – 10:00 Welcome address - T. Moccetti 10:00 – 10:10 Introduction - G. Soldati

SESSION 1 Process Manufacturing and Regulation of Cell-Based Medical Products Chairmen: G. Astori, R. Giordano

10:10 – 10:35 The new Swiss regulation- C. Schärer 10:35 – 10:55 GMP regulation- P. Sanesi

10:55 – 11:15 The EU regulation on cell-based medicinal products(CBMP) - F. Bambi 11:15 – 11:25 Discussion

11:25 – 11:45 Coffee break

SESSION 2 GMP Transfer of Clinical Protocols Chairmen: G. Soldati, K.C. Wollert

11:45 – 12:05 GMP cell processing of bone-marrow derived stem cells - G. Astori

12.05 – 12:25 Stem cell- based treatment for acute myocardial infarction: first experience from a controlled pilot phase I/II clinical trial - R. Giordano

12:25 – 12:45 Cardiac progenitor cells therapy of cardiovascular diseases - S. Bardelli 12:45 – 12:55 Discussion

13:20 – 14:00 Lunch - Satellite Symposium

SESSION 3 Stem Cells Differentiation Potential Chairmen: M. Dominici, J. Hill 14:00 – 14:10 Introduction - M. Dominici

14:10 – 14:30 Molecular regulation of cardiac stem cell commitment - A. Leri 14:30 – 14:50 Cardiac stem cells and diabetic cardiomyopathy - J. Kajstura

14:50 – 15:10 Pim-1 kinase modulates cardiac stem cell growth and survival - M. Sussman 15:10 – 15:30 Discussion

15:30 – 15:45 Coffee break

15:45 – 16:05 Microenvironment changes and differentiation potential of bone marrow derived cells: the bone paradigm - M. Dominici

16:05 – 16:25 Epicardial Stem cells and cardiac regeneration - M. Capogrossi

16:25 – 16:45 Trafficking and homing of stem cells to repair the cardiovascular system. How to track the destiny of cells after therapeutic intravascular or intramyocardial delivery - J. Hill

16:45 – 16:55 Discussion

(4)

P R E L I M I N A R Y P R O G R A M W E D N E S D A Y 2N D_{J U L Y 2 0 0 8}

S TEM CELL THERAPY FOR C ARDIOVASCUL AR DISEASES

8:00 – 8:20 Registration

8:20 – 8:30 Introduction - T. Moccetti / P. Anversa SESSION 4 Chronic Ischemic Diseases

Chairmen: G. Vassalli, J. Bartunek, F. Siclari

08:30 – 08:45 Surgical treatment of LV-dysfunction with CD133+ cells - G. Steinhoff 08:45 – 09:00 Adipose-Derived Cells for Chronic Myocardial Ischemia - F. Fernandez-Aviles 09:00 – 09:15 Ongoing Studies

-Bone Marrow MSC for Repair of Chronically Infarcted Myocardium, FIH - J. Bartunek - Bone Marrow derived Cell Therapy in the Stable Phase of Chronic Ischemic

Heart Disease - T. Moccetti / D. Sürder -YNSTEM trial - T. Torre

09:15 – 09:35 Second generation guided mesenchymal stem cells and heart repair - A. Terzic 09:35 – 09:55 Discussion

09:55 – 10:25 Coffee break

SESSION 5 STEMI

Chairmen: R. Corti, J. Hill, R. Giordano

10:25 – 10:40 Intracoronary infusion of bone marrow cells in patients after acute myocardial infarction – from BOOST to BOOST 2; what have we learned? What can we expect? - K. Wollert

10:40 – 10:55 Selected, Enriched Hematopoitic Cells in STEMI - J. Bartunek 10:55 – 11:10 Apollo Trial - E.H.J. Duckers

11:10 – 11:20 SWISS-AMI - D. Sürder

11:20 – 11:35 Demonstration of cell processing in the cell laboratory 11:35 – 11.50 Discussion

11:50 – 12:15 Live case from the cath lab / operating room SESSION 6 Present Controversies and Future Challenges Chairman: Th. Lüscher - Panel: Whole Faculty

12:15 – 12:45 Main Lecture: From the Cell to the Muscle - Th. Lüscher 12:45 – 13:15 Round Table

13:15 – 14:00 Lunch

COMMON PART WITH “5th_{INTERVENTIONAL SYMPOSIUM ON HIGH RISK}

CORONARY INTERVENTIONS MEET THE EXPERTS – MTE2008”

14:00 – 14:30 Welcome address - T. Moccetti / G. Pedrazzini 14:30 – 15:15 Special Guest Lecture

(5)

Muzzano Noranco Breganzona Gentilino Paradiso Vezia Crocifisso Savosa Pregassona Ospedale Civico Stazione FFS Via Tesserete Lugano LUGANO SUD motorway exit LUGANO NORD motorway exit AGNO airport Sorengo F I N A L P R O G R A M M E G E N E R A L I N F O R M A T I O N LOCATION

The Lugano Stem Cell Meeting (SCM 2008) will take place in Lugano, the most important city in the Italian-speaking part of Switzerland. This region is considered to be one of the most beautiful spots in Europe.

VENUE

The Meeting will take place at the Cardiocentro Ticino, which is located on the hill dominating the west of the city, less than 10 minutes walking distance from the central railway station and 10 minutes by taxi from the local airport (Lugano-Agno). The Milan Malpensa Airport is 1 hour by shuttle-bus from Lugano.

By car: motorway exit Lugano Nord.

CLIMATE

July often presents a warm temperature (23-27°C), with possible rain-showers.

CERTIFICATE OF ATTENDANCE

A Certificate of Attendance will be given to the participants attending all sessions of the Meeting.

ACCREDITATION, CME CREDITS

This Meeting is recognised by the following medical societies as accredited continuous education:

EBAC, European Board for Accreditation in Cardiology: 11 CME credits.

Swiss Society of Cardiology: 5 credits, category 1A.

Under the patronage of the “Working Community

Regio Insubrica”.

Under the patronage of the “Swiss Federal Office of Public Health”.

CONFERENCE LANGUAGE

The conference language is English for all sessions. No translation is provided.

REGISTRATION FEES

€ 200 for the entire SCM, from Tuesday 1st_{July 9:50}

a.m. to Wednesday 2nd_{July 3:45 p.m.}

€ 100 for single days.

The deadline for registration is 9th_{June 2008.}

The registration includes access to the scientific sessions and exhibition, all lunches and refreshment breaks of the sessions for which you are registered. Please see the enclosed registration form.

REGISTRATION CANCELLATIONS

Name changes or cancellations will only be accepted in writing. Refund of the registration fee (less 10%)

will only be granted if notification of cancellation has reached the conference secretariat before 9th_{June 2008.}

HOTEL ACCOMMODATION

Participants are responsible for their own hotel booking. For assistance please contact:

Letizia Bettoli Cardiocentro Ticino

Via Tesserete 48 - 6900 Lugano, Switzerland Phone: +41 91 805 38 82 - Fax: +41 91 805 31 67 letizia.bettoli@cardiocentro.org

WEB SITE

On the web site of the Cardiocentro Ticino

www.cardiocentro.org information is available about: • Cardiocentro Ticino

• Venue

• Scientific program

• Conference secretariat contact details

CONFERENCE SECRETARIAT

Please contact the secretariat in case of any query. Kindly send the registration forms to the secretariat at the following address:

Ufficio Congressi Cardiocentro Ticino Via Tesserete 48 - 6900 Lugano Phone: +41 91 805 31 92 Fax: +41 91 805 31 67 congressi@cardiocentro.org

(6)

COURSE DIRECTORS P. Anversa, Boston - USA G. Astori, Lugano - Switzerland T. Moccetti, Lugano - Switzerland G. Soldati, Lugano - Switzerland D. Sürder, Lugano - Switzerland FACULTY

F. Bambi, Firenze - Italy

S. Bardelli, Lugano - Switzlerland J. Bartunek, Aalst - Belgium M. Capogrossi, Milano - Italy R. Corti, Zürich - Switzerland M. Dominici, Modena - Italy

E.H.J. Duckers, Rotterdam - The Netherlands

C O U R S E D I R E C T O R S - F A C U L T Y

F. Fernandez-Aviles, Madrid - Spain (contacted) R. Giordano, Milano - Italy

J. Hill, London - UK J. Kajstura, Boston - USA A. Leri, Boston - USA

Th. Lüscher, Zürich - Switzerland P. Pesenti, Bellinzona - Switzerland P. Sanesi, Poggibonsi - Italy C. Schärer, Bern - Switzerland F. Siclari, Lugano - Switzlerland G. Steinhoff, Rostock - Deutschland M. Sussman, San Diego - USA A. Terzic, Rochester - USA G. Vassalli, Lausanne - Switzerland K.C. Wollert, Hannover - Deutschland

(7)

Lugano Stem Cell Meeting 1st_-2nd_{July 2008} Cardiocentro Ticino Lugano - Switzerland

R E G I S T R A T I O N F O R M

For individual participant

D E A D L I N E F O R R E G I S T R A T I O N

9

T H

_{J U N E 2 0 0 8}

T O B E R E T U R N E D W I T H E N C L O S U R E S T O

Cardiocentro Ticino Congress Management

Via Tesserete 48 - CH-6900 Lugano

Phone +41 91 805 31 92 - Fax +41 91 805 31 67

congressi@cardiocentro.org

Family name Institute Department Institute Address Institute Postal code (int. Code: ++) e-mail First name City Tel. Country Fax

Registration fees Euro 200 for the entire SCM, from Tuesday

1st_{July 9:50 a.m. to Wednesday 2}nd_July

3:45 p.m.

Payment I have instructed my bank to transfer the amount due with no costs to the beneficiary to

Banca della Svizzera Italiana, account n. A339092F, Fondazione Cardiocentro, Congressi, 6900 Lugano Switzerland, with reference “(participant’s name)” and enclosed is a copy of the transfer. SWIFT CODE: BSILCH22 - IBAN CODE: CH84084650000A339092F

Euro 100 for single days. Please tick as appropriate:

Tuesday 1st_{July 2008}

Wednesday 2nd_{July 2008}

I would like to receive the brochure of the 5th Interventional Symposium on High Risk Coronary Intervention – Meet the Experts 2008

I would like assistance for hotel accomoda-tion, please contact me:

by phone: by fax: