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Supplementary webappendix

This webappendix formed part of the original submission and has been peer reviewed.

We post it as supplied by the authors.

Supplement to: Study Group on Death Rates at High CD4 Count in Antiretroviral Naive

Patients. Death rates in HIV-positive antiretroviral-naive patients with CD4 count greater

than 350 cells per μL in Europe and North America: a pooled cohort observational study.

Lancet 2010; published online July 16. DOI:10.1016/S0140-6736(10)60932-4.

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AMACS

Steering Committee: Antoniadou A., Gargalianos-Kakolyris P., Katsarou O., Kordossis T., Lazanas M., Panos G., Paparizos V., Paraskevis D., Petrikkos G., Sambatakou H., Skoutelis A., Touloumi G. (Chair). Coordinating Center: Department of Hygiene, Epidemiology and Medical Statistics, Athens

University Medical School, Greece (Touloumi G., Paraskevis D., Pantazis N., Bakoyannis G, Gioukari V.)

ATHENA

The ATHENA database is supported by a grant from the Dutch Health Minister and was set up and is maintained by the Stichting HIV Monitoring. The physicians and data analysts include (*Site coordinating physicians): Prof. dr. F. de Wolf (director), Dr. D.O. Bezemer, Drs. L.A.J. Gras, Drs. A.M. Kesselring, Dr. A.I. van Sighem, Dr. C. Smit, Drs. S. Zhang (data analysis group), Drs. S. Zaheri (data collection), Stichting HIV Monitoring, Amsterdam; Dr. J.M. Prins*, Drs. J.C. Bos, Dr. J.K.M. Eeftinck-Schattenkerk, Dr. S.E. Geerlings, Dr. M.H. Godfried, Prof. dr. J.M.A. Lange, Dr. J.T.M. van der Meer, Dr. F.J.B. Nellen, Dr. T. van der Poll, Prof. dr. P. Reiss, Drs. S.U.C. Sankatsing, Drs. M. van der Valk, Drs. J.N. Vermeulen, Drs. S.M.E.

Vrouenraets, Dr. M. van Vugt, Dr. F.W.M.N. Wit, Academisch Medisch Centrum bij de Universiteit van Amsterdam, Amsterdam; Dr. G. Schreij*, Dr. S. van der Geest, Dr. A. Oude Lashof, Dr. S. Lowe, Dr. A. Verbon, Academisch Ziekenhuis Maastricht; Maastricht; Dr. B. Bravenboer*, Drs. M.J.H. Pronk, Catharina Ziekenhuis, Eindhoven; Prof. dr. T.W. Kuijpers, Drs. D. Pajkrt, Dr. H.J. Scherpbier, Emma Kinderziekenhuis, AMC, Amsterdam; Dr. M.E. van der Ende*, Drs. H. Bax, Drs. M. van der Feltz, Dr. L.B.S. Gelinck, Dr. J.L. Nouwen, Dr. B.J.A. Rijnders, Dr. E.D. de Ruiter, Dr. L. Slobbe, Drs. C.A.M. Schurink, Dr. T.E.M.S. de Vries-Sluijs, Erasmus MC, Rotterdam; Dr. G. Driessen, Dr. N.G. Hartwig, Erasmus MC – Sophia, Rotterdam; Dr. J. Branger, Drs. M.H. Hoogewerf, Flevoziekenhuis, Almere; Dr. R.H. Kauffmann*, Dr. E.F. Schippers, Haga Ziekenhuis, locatie Leyenburg, Den Haag; Dr. P.H.P. Groeneveld*, Dr. M.A. Alleman, Isala Klinieken, Zwolle; Prof. dr. R.W. ten Kate*, Dr. R. Soetekouw, Kennemer Gasthuis, Haarlem; Dr. F.P. Kroon*, Dr. S.M. Arend, Drs. M.G.J. de Boer, Prof. dr. P.J. van den Broek, Prof. dr. J.T. van Dissel, Drs. C. van Nieuwkoop, Leids Universitair Medisch Centrum, Leiden; Dr. J.G. den Hollander*, Maasstadziekenhuis, locatie Clara, Rotterdam; Dr. W. Bronsveld*, Dr. K. Pogany, Medisch Centrum Alkmaar, Alkmaar; Dr. R. Vriesendorp*, Dr. E.M.S. Leyten, Medisch Centrum Haaglanden, locatie Westeinde, Den Haag; Dr. D. van Houte*, Dr. M.B. Polée, Dr. M.G.A. van Vonderen, Medisch Centrum Leeuwarden, Leeuwarden; Dr. C.H.H. ten Napel*, Dr. G.J. Kootstra, Medisch Spectrum Twente, Enschede; Prof. dr. K.

Brinkman*, Drs. G.E.L. van den Berk, Dr. W.L. Blok, Dr. P.H.J. Frissen, Drs. W.E.M. Schouten, Onze Lieve Vrouwe Gasthuis, Amsterdam; Dr. A. van Eeden*, Dr. D.W.M. Verhagen, St. Medisch Centrum Jan van Goyen, Amsterdam; Dr. J.W. Mulder*, Dr. E.C.M. van Gorp, Dr. J. Wagenaar, Slotervaart Ziekenhuis, Amsterdam; Dr. J.R. Juttmann*, Dr. M.E.E. van Kasteren, St. Elisabeth Ziekenhuis, Tilburg; Dr. J. Veenstra*, Dr. K.D. Lettinga. St. Lucas Andreas Ziekenhuis, Amsterdam; Dr. P.P. Koopmans*, Drs. A.M. Brouwer, Dr. A.S.M. Dofferhoff, Dr. M. van der Flier, Prof. dr. R. de Groot, Drs. H.J.M. ter Hofstede, Dr. M. Keuter, Dr. A.J.A.M. van der Ven, Universitair Medisch Centrum St. Radboud, Nijmegen; Dr. H.G. Sprenger*, Dr. S. van Assen, Dr. C.J. Stek, Universitair Medisch Centrum Groningen, Groningen; Dr. R. Doedens, Dr. E.H. Scholvinck, Universitair Medisch Centrum Groningen, Beatrix Kliniek, Groningen; Prof. dr. I.M. Hoepelman*, Prof. dr. M.J.M. Bonten, Dr. P.M. Ellerbroek, Drs. E. Hoornenborg, Drs. C.A.J.J. Jaspers, Drs. L.J. Maarschalk-Ellerbroek, Dr. T. Mudrikova, Dr. J.J. Oosterheert, Dr. E.J.G. Peters, Dr. M.M.E. Schneider, Drs. M.W.M. Wassenberg, Dr. S. Weijer, Universitair Medisch Centrum Utrecht, Utrecht; Dr. S.P.M. Geelen, Dr. T.F.W. Wolfs, Wilhelmina Kinderziekenhuis, UMC Utrecht, Utrecht; Prof. dr. S.A. Danner*, Dr. M.A. van Agtmael, Drs. W.F.W.

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Bierman, Drs. F.A.P. Claessen, Drs. M.E. Hillebrand, Drs. E.V. de Jong, Drs. W. Kortmann, Dr. R.M. Perenboom, Drs. E.A. bij de Vaate, VU Medisch Centrum, Amsterdam; Dr. C. Richter*, Drs. J. van der Berg, Dr. E.H. Gisolf, Ziekenhuis

Rijnstate, Arnhem; Dr. A.A. Tanis*, Ziekenhuis Walcheren, Vlissingen; Dr. A.J. Duits, Dr. A. Durand, Dr. F. Muskiet, Dr. R. Voigt, Dr. K. Winkel, St. Elisabeth

Hospitaal/Stichting Rode Kruis Bloedbank, Willemstad, Curaçao.

Brussels St Pierre

The members of the Brussels Saint Pierre Cohort are N. Clumeck (Head of Unit), S. De Wit (Cohort Coordinator), M. Delforge (Biostatistician), C. Necsoi (Data Manager), R. Demeester, A-F. Gennotte, M. Gerard, M-P Guillaume, P. Hermans, K. Kabeya, D. Konopnicki, C. Martin, A. Libois, M-C Payen, P. Semaille, Y. Van Laethem

CASCADE

Steering Committee: Julia Del Amo (Chair), Laurence Meyer (Vice Chair), Heiner C. Bucher, Geneviève Chêne, Deenan Pillay, Maria Prins, Magda Rosinska, Caroline Sabin, Giota Touloumi. Co-ordinating Centre: Kholoud Porter (Project Leader), Sara Lodi, Kate Coughlin, Sarah Walker, Abdel Babiker. Clinical Advisory Board: Heiner Bucher, Andrea de Luca, Martin Fisher, Roberto Muga. Collaborators: Australia Sydney AIDS Prospective Study and Sydney Primary HIV Infection cohort (John Kaldor, Tony Kelleher, Tim Ramacciotti, Linda Gelgor, David Cooper, Don Smith); Canada South Alberta clinic (John Gill); Denmark Copenhagen HIV Seroconverter Cohort (Louise Bruun Jørgensen, Claus Nielsen, Court Pedersen); Estonia Tartu Ülikool (Irja Lutsar); France Aquitaine cohort (Geneviève Chêne, Francois Dabis, Rodolphe Thiebaut, Bernard Masquelier), French Hospital Database (Dominique Costagliola, Marguerite Guiguet), Lyon Primary Infection cohort (Philippe Vanhems), French PRIMO cohort (Marie-Laure Chaix, Jade Ghosn), SEROCO cohort (Laurence Meyer, Faroudy Boufassa); Germany German cohort (Osamah Hamouda, Claudia Kucherer, Barbara Bartmeyer); Greece Greek Haemophilia cohort (Giota Touloumi, Nikos Pantazis, Angelos Hatzakis, Dimitrios Paraskevis, Anastasia Karafoulidou); Italy Italian Seroconversion Study (Giovanni Rezza, Maria Dorrucci, Claudia Balotta), ICONA cohort (Antonella d’Arminio Monforte, Alessandro Cozzi-Lepri, Andrea De Luca.) Netherlands Amsterdam Cohort Studies among homosexual men and drug users (Maria Prins, Jannie van der Helm, Hanneke Schuitemaker, Ronald Geskus); Norway Oslo and Ulleval Hospital cohorts (Mette Sannes, Oddbjorn Brubakk, Anne Eskild, Johan N Bruun); Poland National Institute of Hygiene (Magdalena Rosinska, Joanna Gniewosz); Portugal Universidade Nova de Lisboa (Ricardo Camacho); Russia Pasteur Institute (Tatyana Smolskaya); Spain Badalona IDU hospital cohort (Roberto Muga, Jordi Tor), Barcelona IDU Cohort (Patricia Garcia de Olalla, Joan Cayla), Madrid cohort (Julia Del Amo, Jorge del Romero), Valencia IDU cohort (Santiago Pérez-Hoyos); Switzerland Swiss HIV Cohort Study (Heiner C. Bucher, Martin Rickenbach, Patrick Francioli); Ukraine Perinatal Prevention of AIDS Initiative (Ruslan Malyuta); United Kingdom Edinburgh Hospital cohort (Ray Brettle), Health Protection Agency (Valerie Delpech, Sam Lattimore, Gary Murphy, John Parry, Noel Gill), Royal Free haemophilia cohort (Caroline Sabin, Christine Lee), UK Register of HIV Seroconverters (Kholoud Porter, Anne Johnson, Andrew Phillips, Abdel Babiker, Janet Darbyshire, Valerie Delpech), University College London (Deenan Pillay), University of Oxford (Harold Jaffe).

Cologne-Bonn

Gerd Fätkenheuer, Jürgen Rockstroh, Jan-Christian Wasmuth. Data management: Janne Vehreschild and Caroline Hertenstein.

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Steering commitee: Juan Berenguer, Julia del Amo, Federico García, Félix Gutiérrez, Pablo Labarga, Santiago Moreno y María Ángeles Muñoz.

Field work, data management and statistical analyses: Ana María Caro-Murillo, Paz Sobrino Vegas, Santiago Pérez-Cachafeiro, Inmaculada Jarrín, Belén Alejos Ferreras, BioBank: María Ángeles Muñoz, Isabel García.

Hospitals

Hospital Universitario de Canarias (Santa Cruz de Tenerife): Juan Luis Gómez Sirvent, Patricia Rodríguez Fortúnez, María Remedios Alemán Valls, María del Mar Alonso Socas, Ana María López Lirola, María Inmaculada Hernández Hernández, Felicitas Díaz-Flores. Hospital Carlos III (Madrid): Vicente Soriano, Pablo Labarga, Pablo Barreiro, Carol

Castañares, Pablo Rivas, Andrés Ruiz, Francisco Blanco, Pilar García, Mercedes de Diego. Hospital Doce de Octubre (Madrid): Rafael Rubio, Federico Pulido, Silvana Fiorante, Jara Llenas.

Hospital Donostia (San Sebastián): José Antonio Iribarren, Julio Arrizabalaga, María José Aramburu, Xabier Camino, Francisco Rodríguez-Arrondo, Miguel Ángel von Wichmann, Lidia Pascual Tomé, Miguel Ángel Goenaga, Mª Jesús Bustinduy

Hospital General Universitario de Elche (Elche): Félix Gutiérrez, Mar Masiá, José Manuel Ramos, Sergio Padilla, Victoria Sánchez, Clara Escolano, Fernando Montolio, Yolanda Peral, Catalina Robledano García

Hospital Gregorio Marañón (Madrid): Juan Berenguer, Juan Carlos López Bernaldo de Quirós, Pilar Miralles, Jaime Cosín Ochaíta, Matilde Sánchez Conde, Isabel Gutiérrez Cuellar, Margarita Ramírez Schacke, Belén Padilla Ortega

Hospital Universitari de Tarragona Joan XXIII, IISPV, Universitat Rovira i Virgili (Tarragona): Francesc Vidal, Joaquín Peraire, Consuelo Viladés, Sergio Veloso, Marta Sanjuan, Montserrat Vargas, Miguel López-Dupla, Montserrat Olona.

Hospital de la Princesa (Madrid): Ignacio de los Santos, Jesús Sanz Sanz, Johana Rodríguez

Hospital San Pedro-CIBIR (Logroño): José Antonio Oteo, José Ramón Blanco, Valvanera Ibarra, Luis Metola, Mercedes Sanz, Laura Pérez-Martínez

Hospital de Navarra (Pamplona): Julio Sola Boneta, Javier Uriz, Jesús Castiello, Jesús Reparaz, María Jesús Arraiza, Carmen Irigoyen.

Hospital Ramón y Cajal (Madrid): Santiago Moreno, José Luis Casado, Fernando Dronda, Ana Moreno, María Jesús Pérez Elías, Dolores López, Carolina Gutiérrez, Beatriz

Hernández, María Pumares, Paloma Martí.

Hospital San Cecilio (Granada): Federico García García, José Hernández Quero, Alejandro Peña Monje, Leopoldo Muñoz Medina, Jorge Parra Ruiz.

Danish HIV Cohort Study

Steering commitee and members of The Danish HIV Cohort Study are N. Obel, J Gerstoft, G. Kronborg, B. Røge, C.S.Larsen, G. Pedersen, A.L. Laursen, L. Nielsen, J. Jensen.

EuroSIDA

The multi-centre study group on EuroSIDA (national coordinators in parenthesis). Argentina: (M Losso), C Elias, Hospital JM Ramos Mejia, Buenos Aires. Austria: (N Vetter), Pulmologisches Zentrum der Stadt Wien, Vienna; R Zangerle, Medical University Innsbruck, Innsbruck. Belarus: (I Karpov), A Vassilenko, Belarus State Medical University, Minsk, VM Mitsura, Gomel State Medical University, Gomel; O Suetnov, Regional AIDS Centre, Svetlogorsk. Belgium: (N Clumeck), S De Wit, M Delforge, Saint-Pierre Hospital, Brussels; R Colebunders, Institute of Tropical Medicine, Antwerp; L Vandekerckhove, University Ziekenhuis Gent, Gent. Bosnia-Herzegovina: (V Hadziosmanovic), Klinicki Centar Univerziteta Sarajevo, Sarajevo. Bulgaria: (K Kostov), Infectious Diseases Hospital, Sofia. Croatia: (J Begovac), University Hospital of Infectious Diseases, Zagreb. Czech Republic: (L Machala), H

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Rozsypal, Faculty Hospital Bulovka, Prague; D Sedlacek, Charles University Hospital, Plzen. Denmark: (J Nielsen), G Kronborg,T Benfield, M Larsen, Hvidovre Hospital, Copenhagen; J Gerstoft, T Katzenstein, A-B E Hansen, P Skinhøj,

Rigshospitalet, Copenhagen; C Pedersen, O D Larsen, Odense University Hospital, Odense; L Oestergaard, Skejby Hospital, Aarhus. Estonia: (K Zilmer), West-Tallinn Central Hospital, Tallinn; Jelena Smidt, Nakkusosakond Siseklinik, Kohtla-Järve. Finland: (M Ristola), Helsinki University Central Hospital, Helsinki. France: (C Katlama), Hôpital de la Pitié-Salpétière, Paris; J-P Viard, Hôpital Necker-Enfants Malades, Paris; P-M Girard, Hospital Saint-Antoine, Paris; JM Livrozet, Hôpital Edouard Herriot, Lyon; P Vanhems, University Claude Bernard, Lyon; C Pradier, Hôpital de l'Archet, Nice; F Dabis, D Neau, Unité INSERM, Bordeaux. Germany: (J Rockstroh), Universitäts Klinik Bonn; R Schmidt, Medizinische Hochschule

Hannover; J van Lunzen, O Degen, University Medical Center Hamburg-Eppendorf, Infectious Diseases Unit, Hamburg; HJ Stellbrink, IPM Study Center, Hamburg; S Staszewski, JW Goethe University Hospital, Frankfurt; J Bogner, Medizinische Poliklinik, Munich; G. Fätkenheuer, Universität Köln, Cologne. Greece: (J Kosmidis), P Gargalianos, G Xylomenos, J Perdios, Athens General Hospital; G Panos, A Filandras, E Karabatsaki, 1st IKA Hospital; H Sambatakou, Ippokration Genereal Hospital, Athens. Hungary: (D Banhegyi), Szent Lásló Hospital, Budapest. Ireland: (F Mulcahy), St. James's Hospital, Dublin. Israel: (I Yust), D Turner, M Burke, Ichilov Hospital, Tel Aviv; S Pollack, G Hassoun, Rambam Medical Center, Haifa; S Maayan, Hadassah University Hospital, Jerusalem. Italy: (A Chiesi), Istituto Superiore di Sanità, Rome; R Esposito, I Mazeu, C Mussini, Università Modena, Modena; C Arici, Ospedale Riuniti, Bergamo; R Pristera, Ospedale Generale

Regionale, Bolzano; F Mazzotta, A Gabbuti, Ospedale S Maria Annunziata, Firenze; V Vullo, M Lichtner, University di Roma la Sapienza, Rome; A Chirianni, E

Montesarchio, M Gargiulo, Presidio Ospedaliero AD Cotugno, Monaldi Hospital, Napoli; G Antonucci, F Iacomi, P Narciso, C Vlassi, M Zaccarelli, Istituto Nazionale Malattie Infettive Lazzaro Spallanzani, Rome; A Lazzarin, R Finazzi, Ospedale San Raffaele, Milan; M Galli, A Ridolfo, Osp. L. Sacco, Milan; A d’Arminio Monforte, Istituto Di Clinica Malattie Infettive e Tropicale, Milan. Latvia: (B Rozentale), I Zeltina, Infectology Centre of Latvia, Riga. Lithuania: (S Chaplinskas), Lithuanian AIDS Centre, Vilnius. Luxembourg: (R Hemmer), T Staub, Centre Hospitalier, Luxembourg. Netherlands: (P Reiss), Academisch Medisch Centrum bij de Universiteit van

Amsterdam, Amsterdam. Norway: (J Bruun), A Maeland, V Ormaasen, Ullevål Hospital, Oslo. Poland: (B Knysz) J Gasiorowski, Medical University, Wroclaw; A Horban, E Bakowska, Centrum Diagnostyki i Terapii AIDS, Warsaw; A Grzeszczuk, R Flisiak, Medical University, Bialystok; A Boron-Kaczmarska, M Pynka, M

Parczewski, Medical Univesity, Szczecin; M Beniowski, E Mularska, Osrodek Diagnostyki i Terapii AIDS, Chorzow; H Trocha, Medical University, Gdansk; E Jablonowska, E Malolepsza, K Wojcik, Wojewodzki Szpital Specjalistyczny, Lodz. Portugal: (F Antunes), E Valadas, Hospital Santa Maria, Lisbon; K Mansinho, Hospital de Egas Moniz, Lisbon; F Maltez, Hospital Curry Cabral, Lisbon. Romania: (D Duiculescu), Spitalul de Boli Infectioase si Tropicale: Dr. Victor Babes, Bucarest. Russia: (A Rakhmanova), Medical Academy Botkin Hospital, St Petersburg; E Vinogradova, St Petersburg AIDS Centre, St Peterburg; S Buzunova, Novgorod Centre for AIDS, Novgorod. Serbia: (D Jevtovic), The Institute for Infectious and Tropical Diseases, Belgrade. Slovakia: (M Mokráš), D Staneková, Dérer Hospital, Bratislava. Slovenia: (J Tomazic), University Clinical Centre Ljubljana, Ljubljana. Spain: (J González-Lahoz), V Soriano, P Labarga, J Medrano, Hospital Carlos III, Madrid; S Moreno, Hospital Ramon y Cajal, Madrid; B Clotet, A Jou, R Paredes, C Tural, J Puig, I Bravo, Hospital Germans Trias i Pujol, Badalona; JM Gatell, JM Miró, Hospital Clinic i Provincial, Barcelona; P Domingo, M Gutierrez, G Mateo, MA Sambeat, Hospital Sant Pau, Barcelona. Sweden: (A Karlsson), Venhaelsan-Sodersjukhuset, Stockholm; L Flamholc, Malmö University Hospital, Malmö.

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Switzerland: (B Ledergerber), R Weber, University Hospital, Zürich; P Francioli, M Cavassini, Centre Hospitalier Universitaire Vaudois, Lausanne; B Hirschel, E Boffi, Hospital Cantonal Universitaire de Geneve, Geneve; H Furrer, Inselspital Bern, Bern; M Battegay, L Elzi, University Hospital Basel. Ukraine: (E Kravchenko), N Chentsova, Kiev Centre for AIDS, Kiev; G Kutsyna, Luhansk State Medical University; Luhansk; S Servitskiy, Odessa Region AIDS Center, Odessa; S Antoniak, Kiev; M Krasnov, Kharkov State Medical University, Kharkov. United Kingdom: (S Barton), St. Stephen's Clinic, Chelsea and Westminster Hospital, London; AM Johnson, D Mercey, Royal Free and University College London Medical School, London (University College Campus); A Phillips, MA Johnson, A Mocroft, Royal Free and University College Medical School, London (Royal Free Campus); M Murphy, Medical College of Saint Bartholomew's Hospital, London; J Weber, G Scullard, Imperial College School of Medicine at St. Mary's, London; M Fisher, Royal Sussex County Hospital, Brighton; C Leen, Western General Hospital, Edinburgh.

Virology group: B Clotet, R Paredes(Central Coordinators) plus ad hoc virologists from participating sites in the EuroSIDA Study.

Steering Committee: F Antunes, B Clotet, D Duiculescu, J Gatell, B Gazzard, A Horban, A Karlsson, C Katlama, B Ledergerber (Chair), A D’Arminio Montforte, A Phillips, A Rakhmanova, P Reiss (Vice-Chair), J Rockstroh

Coordinating Centre Staff: J Lundgren (project leader), O Kirk, A Mocroft, N Friis-Møller, A Cozzi-Lepri, W Bannister, M Ellefson, A Borch, D Podlekareva, J Kjær, L Peters, J Reekie, J Kowalska

Statement of Funding:

Primary support for EuroSIDA is provided by the European Commission BIOMED 1 (CT94-1637), BIOMED 2 (CT97-2713), the 5th Framework (QLK2-2000-00773) and the 6th Framework (LSHP-CT-2006-018632) programs. Current support also includes unrestricted grants by Bristol-Myers Squibb, GlaxoSmithKline, Roche, Gilead, Pfizer, Merck and Co., Tibotec and Boehringer-Ingelheim. The participation of centres from Switzerland was supported by The Swiss National Science

Foundation (Grant 108787).

Frankfurt HIV Cohort

Babacan E. (data management), Bickel M., Bodtländer A., Brodt H-R., Carlebach A., Gute P., Haberl A., Helm E., Khaykin P., Klauke S., Knecht G., Lennemann T., Locher L., Lutz T., Mösch M., Müller A., Nisius G., Staszewski S., Stephan C., Stürmer M. (Virology), von Hentig N., Wolf T.

HAVACS

The members of the HIV Atlanta VA Cohort Study (HAVACS) are: Guest JL, Rimland D, Moanna A, Moorfield M, Dorsey M, Desilva KE, Schlueter Wirtz S, Mindley R, Dozier R, Robinson Y, Brown P.

ICONA

Governing body

M Moroni (chair), G Angarano, A Antinori, G Carosi, R Cauda, A d’Arminio Monforte, G Di Perri, M Galli, F Ghinelli, R Iardino, G Ippolito, A Lazzarin, F Mazzotta, CF Perno, PL Viale, F Von Schlosser.

Steering committee

A Ammassari, A Antinori, C Balotta, P Bonfanti, MR Capobianchi, A Castagna, F Ceccherini-Silberstein, A Cozzi-Lepri, A d’Arminio Monforte, A De Luca, C

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Participating Physicians and Centers

M Montroni, G Scalise, MC Braschi, A Riva (Ancona); U Tirelli, F Martellotta (Aviano-PN); G Pastore, N Ladisa (Bari); F Suter, C Arici (Bergamo); F Chiodo, V Colangeli, C Fiorini, O Coronado (Bologna); G Carosi, G Cristini, C Torti, C Minardi, D Bertelli (Brescia); T Quirino, (Busto Arsizio); PE Manconi, P Piano (Cagliari); E Pizzigallo, M D’Alessandro (Chieti); F Ghinelli, L Sighinolfi (Ferrara); F Leoncini, F Mazzotta, M Pozzi, S Lo Caputo (Firenze); B Grisorio, S Ferrara (Foggia); G Pagano, G Cassola, A Alessandrini, R Piscopo (Genova); F Soscia, L Tacconi (Latina); A Orani, P Perini (Lecco); F Chiodera, P Castelli (Macerata); M Moroni, A Lazzarin, G Rizzardini, L Caggese, A d’Arminio Monforte, A Galli, S. Merli, C Pastecchia, MC Moioli (Milano); R Esposito, C Mussini (Modena); N Abrescia, A Chirianni, M De Marco, R Viglietti (Napoli); C Ferrari, P Pizzaferri (Parma); G Filice, R Bruno (Pavia); G Magnani, MA Ursitti (Reggio Emilia); M Arlotti, P Ortolani (Rimini); R Cauda, A Antinori, G

Antonucci, P Narciso, V Vullo, A De Luca, M Zaccarelli, R Acinapura, P De Longis, MP Trotta, M Lichtner, F Carletti, (Roma); MS Mura, M Mannazzu (Sassari); P Caramello, G Di Perri, GC Orofino, M Sciandra (Torino); E Raise, F Ebo (Venezia); G Pellizzer, D Buonfrate (Vicenza).

Funding

The Icona Foundation Study is supported by unrestricted educational grants from Abbott , Boehringer Ingelheim, Bristol-Myers Squibb, Gilead, GlaxoSmithKline, Pfizer and Janssen-Cilag.

IDD-HSR

Representative of the cohort: Antonella Castagna Data Managers: Stefania Salpietro, Mario Marangione Statistician: Laura Galli

Scientific commmittee: Adriano Lazzarin (representative of the institution) Nicola Gianotti, Francesca Cossarini, Vincenzo Spagnuolo

KOMPNET

Documenting sites (basis-module): Gemeinschaftspraxis Driesener Straße, Berlin • Gemeinschaftspraxis Mehringdamm, Berlin • Gemeinschaftspraxis Turmstraße, Berlin • Gemeinschaftspraxis Fuggerstraße, Berlin •

Praxis-zentrum Kaiserdamm, Berlin • Universitätsklinikum Benjamin Franklin, Charité, Berlin • Dermatologische Klinik, Ruhr-Universität, Bochum •

Universitätsklinikum Dortmund • Uni-versitätsklinikum, Düsseldorf • Medizinische Klinik 3, Universitätsklinikum, Erlangen • Kli-nik für

Dermatologie, Universität Essen • HIVCENTER, Universitätsklinikum, Frankfurt • Ifi-Institut, Hamburg • ICH Grindelpraxis, Infektionsepidemiologisches

Centrum, Hamburg • Medizinische Hochschule, Hannover • Praxis Georgstraße, Hannover • Gemeinschaftspraxis, Kriegsstraße, Karlsruhe • Städtisches

Krankenhaus Kemperhof, Koblenz • Praxis Hohenstau-fenring, Köln •

Gemeinschaftspraxis Isartorplatz, München • MVZ Karlsplatz, HIV Research and Clinical Centre , München • Praxisgemeinschaft Franz Joseph-Straße, München • Klini-kum, Osnabrück • Gemeinschaftspraxis Ulmer/Frietsch/Müller,

Stuttgart Steering Committee: Gabriele Arendt(Speaker of the Clinical Science Board), Norbert H. Brockmeyer (Chair KompNet), Stefan Esser (Representative of the Sites), Annette Haberl(Speaker of the Gender & Pediatric Studies Board), Hans Jäger(Representative of the Sites), Siegfried Schwarze (Representative of the Patients Council), Matthias Stoll (Speaker of the Social Sciences & Public Health Board), Hans Wolf (Speaker of the Basic & Translational Research Board), Klaus Jansen (Cohort Manager),

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Claudia Michalik (Data Manager), Adriane Skaletz-Rorowski (Scientific Coordinator) Children Cohort: Christoph Königs (Speaker); Pregnant Women Cohort: Andrea Gingelmaier (Speaker) The KompNet is supproted by the Federal Ministry of Education and Research and the Ruhr-Universität Bochum.

MACS

Data in this manuscript were collected by the Multicenter AIDS Cohort Study (MACS) with centers (Principal Investigators) at The Johns Hopkins Bloomberg School of Public Health (Joseph B. Margolick, Lisa P. Jacobson), Howard Brown Health Center, Feinberg School of Medicine, Northwestern University, and Cook County Bureau of Health Services (John P. Phair, Steven M. Wolinsky), University of California, Los Angeles (Roger Detels), and University of Pittsburgh (Charles R. Rinaldo). The MACS is funded by the National Institute of Allergy and Infectious Diseases, with additional supplemental funding from the National Cancer Institute. 35042, 5-MO1-RR-00052 (GCRC), 35043, 35039, UO1-AI-35040, UO1-AI-35041.

Website located at http://www.statepi.jhsph.edu/macs/macs.html.

MANIF 2000

Cohort Management Team: C. Boirot, AD. Bouhnik, MP. Carrieri, JP. Cassuto, M. Chesney, J. Cohen, P. Dellamonica, P. Dujardin, H. Gallais, JA. Gastaut, P. Kurkdji, G. Lepeu, D. Mechali, JP. Moatti, J. Moreau, M. Nègre, Y. Obadia, I. Poizot-Martin, C. Pradier, M . Préau, D. Rey, P. Roux, C. Rouzioux, A. Sobel, B. Spire, F.

Trémolières, V. Villes, E. Vincent, D. Vlahov.

Modena

Cohort representative: Cristina Mussini. Data management: Vanni Borghi.

Montreal Chest Immunodeficiency Cohort

The cohort was founded by Richard Lalonde and has received infrastructure funding from the Fonds de recherche en santé du Québec, Réseau SIDA/maladies

infectieuses (FRSQ). Marina Klein is supported by a Chercheur-Boursier clinicien senior career award from the FRSQ.

PISCIS

Coordinators: J. Casabona (CEEISCAT-Autonomous University of Barcelona (UAB) Jose M. Miró (Hospital Clínic-Idibaps, Universitat de Barcelona). Field

coordinator: Alvaro J. Betancourt (CEEISCAT). Steering committee: J. Casabona, A. Esteve, A. Betancourt (CEEISCAT), Jose M. Miró (Hospital Clínic-Idibaps,

Universitat de Barcelona), D. Podzamczer (Hospital de Bellvitge de Barcelona), J. Murillas (Hospital Son Dureta de Mallorca). Scientific committee: JM Gatell, M López-Dieguez-Puerta (Hospital Clínic-Idibaps, Universitat de Barcelona), C. Tural, B. Clotet (Hospital Universitari Germans Trias i Pujol, Universitat Autónoma de Barcelona), E. Ferrer (Hospital de Bellvitge de L’Hospitalet), M. Riera (Hospital Son Dureta de Mallorca), F. Segura, G. Navarro (Corporació Parc Taulí de Sabadell), L. Force (Hospital de Mataró), J. Vilaró (Hospital de Vic), A. Masabeu (Hospital de Palamós), I. García (Hospital General d’Hospitalet), M.Guadarrama (Hospital Alt Penedès de Vilafranca), A. Romero, C. Agustí (CEEISCAT). Data Management and statistical analysis: A. Esteve, A. Montoliu, N. Ortega (CEEISCAT), I. Pérez (Hospital Clínic- Idibaps, Universitat de Barcelona). Technical support: A Montoliu (CEEISCAT) M. Sanchez (Hospital Clínic- Idibaps, Universitat de Barcelona).

Clinicians involved: JL Blanco, F. Garcia-Alcaide, E. Martínez, J. Mallolas, M. López-Dieguez, C Manzardo, (Hospital Clínic- Idibaps, Universitat de Barcelona), G. Sirera, J. Romeu, A. Jou. E. Negredo, C. Miranda, MC Capitan (Hospital Universitari

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Germans Trias i Pujol, Universitat Autónoma de Barcelona), M. Olmo, P. Barragan, M. Saumoy, F. Bolao, C. Cabellos, C. Peña. (Hospital Universitari de Bellvitge, L’Hospitalet, Barcelona), M. Sala, M. Cervantes, Mª Jose Amengual, M. Navarro, E Penelo (Corporació Sanitària Parc Taulí), P. Barrufet (Hospital de Mataró), M. Guadarrama (Hospital Alt Penedès de Vilafranca). Financial support : FIPSE (Madrid) and the Direcció General de Salut Pública, Departament de Salut. Generalitat de Catalunya (Barcelona).

Southern Alberta Cohort

Cohort representative: John Gill.

Swiss HIV Cohort Study

The members of the Swiss HIV Cohort Study are Battegay M, Bernasconi E, Böni J, Bucher HC, Bürgisser P, Calmy A, Cavassini M, Dubs R, Egger M, Elzi L, Fischer M, Flepp M, Fontana A, Francioli P (President of the SHCS), Furrer H (Chairman of the Clinical and Laboratory Committee), Fux CA, Gorgievski M, Günthard HF (Chairman of the Scientific Board), Hirsch HH, Hirschel B, Hösli I, Kahlert C, Kaiser L, Karrer U, Kind C, Klimkait T, Ledergerber B, Martinetti G, Martinez de Tejada B, Müller N, Nadal D, Paccaud F, Pantaleo G, Rauch A, Regenass S, Rickenbach M (Head of Data Center), Rudin C (Chairman of the Mother & Child Substudy), Schmid

P,Schultze D, Schöni-Affolter F, Schüpbach J, Speck R, Taffé P, Telenti A, Trkola A, Vernazza P, Weber R, Yerly S. The Swiss HIV Cohort Study is supported by the Swiss National Finance Foundation.

UK CHIC

UK CHIC Steering Committee: Jonathan Ainsworth, Jane Anderson, Abdel Babiker, Valerie Delpech, David Dunn, Philippa Easterbrook, Martin Fisher, Brian Gazzard, Richard Gilson, Mark Gompels, Teresa Hill, Margaret Johnson, Clifford Leen, Chloe Orkin, Adrian Palfreeman, Andrew Phillips, Deenan Pillay, Kholoud Porter, Caroline Sabin, Achim Schwenk, John Walsh.

Central co-ordination: Research Department of Infection & Population Health, UCL Medical School, London (Loveleen Bansi, Teresa Hill, Andrew Phillips, Caroline Sabin); Medical Research Council Clinical Trials Unit (MRC CTU), London (David Dunn, Adam Glabay, Kholoud Porter).

Participating centres: Barts and The London NHS Trust, London (Chloe Orkin, Kevin Jones, Rachel Thomas); Brighton and Sussex University Hospitals NHS Trust

(Martin Fisher, Nicky Perry, Anthony Pullin, Duncan Churchill); Chelsea and

Westminster NHS Trust, London (Brian Gazzard, Steve Bulbeck, Sundhiya Mandalia, Jemima Clarke); Health Protection Agency Centre for Infections London (Valerie Delpech); Homerton University Hospital NHS Trust, London (Jane Anderson, Sajid Munshi); King’s College Hospital, London (Philippa Easterbrook, Frank Post, Yasar Khan, Paragi Patel, Fatimah Karim, Stephen Duffell); Medical Research Council Clinical Trials Unit (MRC CTU), London (Abdel Babiker, David Dunn, Adam Glabay, Kholoud Porter); UCL Medical School and The Mortimer Market Centre, London

(Richard Gilson, Shuk-Li Man, Ian Williams); North Bristol NHS Trust (Mark Gompels, Debbie Dooley); North Middlesex University Hospital NHS Trust, London (Achim Schwenk); Royal Free NHS Trust and Department of Infection & Population Health, UCL Medical School, London (Margaret Johnson, Mike Youle, Fiona Lampe, Colette Smith, Helen Grabowska, Clinton Chaloner, Dewi Ismajani Puradiredja, Loveleen Bansi, Teresa Hill, Andrew Phillips, Caroline Sabin); Imperial College Healthcare NHS Trust, London (Nicky Mackie, Alan Winston, Jonathan Weber, Christian Kemble, Mark Carder); The Lothian University Hospitals NHS Trust, Edinburgh

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(Clifford Leen, Alan Wilson); University Hospitals of Leicester, Leicester (Adrian Palfreeman, Anne Moore).

WIHS

Data in this manuscript were collected by the Women's Interagency HIV Study (WIHS) Collaborative Study Group with centers (Principal Investigators) located at: New York City/Bronx Consortium (Kathryn Anastos); Brooklyn, NY (Howard Minkoff); Washington DC Metropolitan Consortium (Mary Young); The Connie Wofsy Study Consortium of Northern California (Ruth Greenblatt); Los Angeles County/Southern California Consortium (Alexandra Levine); Chicago Consortium (Mardge Cohen); Data Analysis Center, Johns Hopkins University (Stephen Gange). The WIHS is funded by the National Institutes of Health.

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