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T cells expressing chimeric antigen receptor promote immune tolerance

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Figure

Figure 1. mAbCAR construct and its expression in transfected T cells and Tregs. (A) mAbCAR construct scheme
Figure 2. mAbCAR-expressing T cells are activated by FITC binding. (percentage of surface expression of selected markers measured by flow cytometry (CD69, LAG3, PD1) before or after in vitro exposure to FITC (24 hours) in untransfected CD4A) Analysis of mA
Figure 5. FITC-H-2DdMHC-I alloantigen.-mAbCAR Tregs induce tolerance to allogeneic pancreatic islet grafts if directed against the islet  (A) Experimental scheme
Figure 6. FITC-H-2Ddlogic sections of allogeneic pancreatic grafts in mice that received no Treg treatment, GFP10 days after transplantation and Treg transfer (arrows = pancreatic islets under the kidney capsule)
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