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The involvement of tau in nucleolar transcription and the stress response

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Figure

Fig. 1 Tau localises to the nucleolus in undifferentiated and differentiated Neuroblastoma (SHSY5Y) cells.differentiated (with T-Tau antibody using 10 nm gold particle-conjugated secondary antibody showed tau gold particles within the Nucleolus (1).Nucleus
Fig. 2 Tau localises with TIP5 and impacts on rDNA transcription and heterochromatin. Immunoprecipitation from whole cell lysates showed thatthe knockdown cells showed a significant increase in 45S-pre-rRNA synthesis (rDNA transcription), 18S rRNA and 28S
Fig. 3 Nucleolar stress co-occurs with the redistribution of nucleolar nP-Tau.well as FBL redistribution from nP-Tau (white arrows) compared to the control
Fig. 4 Cellular stress induces nuclear accummulation of P-Tau which does not colocalise with nucleolar markers
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