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Melatonin attenuates palmitic acid-induced mouse granulosa cells apoptosis via endoplasmic reticulum stress

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Figure

Fig. 1 Schematic of the experimental design. Mouse granulosa cellswere collected from the ovaries of immature female mice and thentreated with PA, PA + melatonin, PA + 4-PBA or TG + melatonin toexplore the mechanism of melatonin that protects against PA-induced cell apoptosis
Fig. 2 Effect of PA on the growth and apoptosis of mouse granulosa cells. a Cells were treated with different concentrations (100-800 μM) of PAfor 24 h and then processed for the cell activity analysis
Fig. 4 Effect of PA on ER stress-related protein expression in mouse granulosa cells.800after treatment with different doses of PA (100-800 a Expression of GRP78 and CHOP in mouse granulosa cells μM) for 24 h
Fig. 6 Effects of melatonin on PA-induced mouse granulosa cell apoptosis and apoptosis-related gene expression.after treatment with different concentrations of melatonin (0.1-100cells after treatment with different concentrations of melatonin (0.1-100ofexp
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