5 Th. 5 th Lugano Stem Cell Meeting. 20 th 21 st June Università della Svizzera Italiana Lugano Switzerland PRELIMINARY PROGRAM

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5

th

Lugano

Stem Cell

Meeting

20

th

– 21

st

June

2016

Università della Svizzera Italiana

Lugano

Switzerland

5

Th

P R E L I M I N A R Y P R O G R A M

Poster submission is now

open for registration

Deadline June 10

th

, 2016

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Introduction

Basic and translational research on stem cells

for regenerating injured organs, including the

heart and the brain, has experienced tremendous

progress over the past decade. Besides cell types

traditionally used in regenerative protocols, such

as bone marrow-derived cells and mesenchymal

stem cells, new candidate cell types for cardiac

repair have emerged, most notably

cardiac-resident stem and progenitor cells. Meanwhile,

induced pluripotent stem (iPS) cells provide a

unique opportunity of disease modelling and

personalized medicine. The roles of molecular

mediators of stem cell effects, such as paracrine

factors including exosomes and noncoding RNA,

are increasingly well understood and exploited in

therapeutic strategies.

The fifth edition of the Lugano Stem Cell

Meet-ing provides a unique opportunity to discuss the

above scientific issues with worldwide leaders

in the field within a particularly comfortable

context. As for the previous editions of the

Meet-ing, the first day will be focused on basic research

while the second day will be more specifically

devoted to clinical applications and cell therapy

trials. Spotlight sessions of this edition will

highlight exosomes as paracrine mediators of

functional effects of stem cells, noncoding RNA

as critical regulators of cell function, and stem

cell-based approaches for the treatment of

neu-rological diseases.

We look forward to welcoming you in Lugano,

Prof. Tiziano Moccetti,

Prof. Giuseppe Vassalli,

Dr. Lucio Barile,

Dr. Daniel Sürder

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M O R N I N G M O N D A Y 2 0T H J U N E 2 0 1 6

08:30 – 09:00 Registration

09:00 – 09:10 Welcome Address - T. Moccetti

09:10 – 09:20 Introduction - G. Vassalli

SESSION 1 Cellular and non cellular approaches for heart disfunction Chairman: G. Pompilio

Panel: O. Binah, P. Ferdinandy, C. Gaetano

09:20 – 09:35 Autophagy-lysosomal pathway alterations in heart failure - A. Beltrami

09:35 – 09:50 Fate of cardiac stem cells in the adult heart - A. Leri

09:50 – 10:05 Long non-coding RNAs in post-ischemic heart failure - F. Martelli

10:05 – 10:35 Lecture

Molecular approaches for cardiac regeneration - M. Giacca

10:35 – 11:00 Coffee break- POSTER SESSION

SESSION 2 Extracellular vesicles: Emerging biomarkers and therapeutics Chairman: A. Leri

Panel: G. Camussi, T. Tallone, G.Vassalli

11:00 – 11:15 Heterogeneous populations of extracellular vesicle subtypes - J.P. Sluijter

11:15 – 11:30 Cardiac exosomes for cardiac repair - L. Barile

11:30 – 11:45 Functional genomics of cardioprotection: role microRNAs and exosomes P. Ferdinandy

Lecture

11:45 – 12:15 Exosomes as therapeutic agents - E. Marbán

12:15 – 13:10 Lunch- POSTER SESSION M O N D A Y 2 0T H J U N E 2 0 1 6

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M O N D A Y 2 0t h J U N E 2 0 1 6

A F T E R N O O N M O N D A Y 2 0 t h J U N E 2 0 1 6

SESSION 3 Cardiomyocytes specification from ESC or iPS Chairman: J.P. Sluijter

Panel: C. Altomare, L. Barile, A.Beltrami

13:10 – 13:25 iPS cell-derived cardiomyocytes - P. Dell’Era

13:25 – 13:40 Mathematical modelling of the action potential of human embryonic stem cell derived cardiomyocytes.- M. Jaconi

13:40 – 13:55 Electrophysiology of iPS cell-derived cardiomyocytes - O. Binah

13:55 – 14:25 Lecture:

Calcium handling in human induced pluripotent stem cell derived cardiomyocytes

L. Gepstein

SESSION 4 Neuroregeneration Chairman: P. Paganetti

Panel: A. Faedo

14:25 – 14:45 Molecular and cellular control of neural stem cell activity - S. Jessberger

14:45 – 15:05 Attempts to characterize the limited capacity of the mammalian retina to regenerate photoreceptors - Y. Arsenijevik

15:05 – 15:35 Lecture

A differentiation toolkit for the derivation of neurons from pluripotent stem cells, the example of Huntington’s Disease

A. Faedo

15:35 – 16:15 Coffee break- POSTER SESSION 16:15 – 16:45 Lecture

Identification and characterization of hypoxia-regulated endothelial circular RNA.

S. Dimmeler

SESSION 5 Vascular aging, regeneration and diabetes Chairman: S. Dimmeler

Panel: V. Lionetti, A. Beltrami

16:45 – 17:00 Epigenetics of diabetes - C. Gaetano

17:00 – 17:15 Molecular mechanisms of age-related endothelial dysfunction and CVD - G. Camici

17:15 – 17:30 Endothelial progenitor cell-derived exosomes - G. Camussi

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M O R N I N G T U E S D A Y 2 1s t J U N E 2 0 1 6

08:00 – 08:20 Registration

08:20 – 08:30 Welcome address - D. Sürder

SESSION 6 How to design animal models in regeneration cardiovascular research translation of the unmet need

Chairman: P. Anversa

Panel: S. Bardelli, J. Kastrup, W. Wojakowski 08:30 – 08:42 Small animal models - V. Lionetti

08:42 – 08:54 Big animal models - M. Emmert

08:54 – 09:05 Discussion

SESSION 7 Now it counts! Update on planned, resumed and ongoing trials Chairman: F. Ruschitzka

Panel: R. Corti, G. Pompilio, A. Zeiher

09:05 – 09:17 The CHART program – preliminary results and future objectives - TBE

09:17 – 09:29 DREAM-HF- Will the dream become true? - E. Perin

09:29 – 09:41 i.c. CD133+ cells in patients with No-option resistant angina results from the REGENT-VSEL trial - W. Wojakowski

09:41 – 09:53 Update on the ALLSTAR program - L. Marbán

09:53 – 10:05 Long term results of the MSC-HF trial - J. Kastrup

10:05 – 10:17 Update on the STEM-AMI OUTCOME trial - F. Achilli

10:17 – 10:29 Study design, rationale and status of the ESCORT trial - P. Menasché

10:29 – 10:45 Discussion

10:45 – 11:15 Coffee break

SESSION 8 The big debate on meta analysis in cardiac regeneration Chairman: A. Mathur

Panel: D. Locca, G. Pedrazzini

11:15 – 11:27 Why I prefer IPD based meta-analyses - M. Gyöngyosi

11:27 – 11:39 Why I prefer publication based meta-analyses - B. Dawn

11:39 – 11:51 How can they come together - A. Zeiher

11:51 – 12:05 Discussion

12:05 – 12:15 Closing Remarks - T. Moccetti

12:15 – 13:30 Lunch

13:30 – 14:15 Special Joint Lecture TBE - O. Atkof

End of the 5th Lugano Stem Cell Meeting

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C O U R S E D I R E C T O R S - F A C U L T Y S P O N S O R S

COURSE DIRECTORS

FACULTY

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G E N E R A L I N F O R M A T I O N

LOCATION

The 5th Lugano Stem Cell Meeting (LSCM) 2016 will

take place in Lugano, the most important city in the Italian speaking part of Switzerland. This region is considered one of the most beautiful spots in Europe.

VENUE

The Symposium will take place at the Università della Svizzera Italiana, which is located 10 minutes walk-ing distance of many hotels, shops and attractions. The venue is centrally located, and 30 minutes by taxi from the local airport (Lugano-Agno). The Milan Mal-pensa Airport is 1 hour by shuttle-bus from Lugano. By car: motorway exit Lugano Nord.

CLIMATE

June often presents a warm temperature (23-27°C), with possible rain-showers.

CERTIFICATE OF ATTENDANCE

A Certificate of Attendance will be given to the par-ticipants attending all sessions of the Symposium.

ACCREDITATION

FAMH: 10,5 credits.

CONFERENCE LANGUAGE

The conference language is English for all sessions. No translation is provided.

POSTER SESSION

Call for abstracts on the website www.cardiocen-tro.org. The best poster will be awarded and will be presented as an oral presentation on June 20th.

Deadline poster submission: June 10th, 2016

HOTEL ACCOMMODATION

Participants are responsible for their own hotel booking. For assistance please contact:

Amiconi Consulting Via Al Forte 10 6900 Lugano, Switzerland Phone: +41 91 921 38 12 Fax: +41 91 921 38 13 info@amiconiconsulting.ch WEB SITE

On the web site of the Cardiocentro Ticino

www.cardiocentro.org/lscm information is available about:

• Cardiocentro Ticino • Venue

• Scientific program

• Conference secretariat contact details • Call for Abstract

• For registration:

www.cardiocentro.org/lscm-registration

CONFERENCE SECRETARIAT

Please contact the secretariat in case of any query at the following address:

Events and Communication Department Cardiocentro Ticino

Via Tesserete 48 - 6900 Lugano Phone: +41 91 805 31 93 / 33 78 Fax: +41 91 805 38 13 congressi@cardiocentro.org

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5 Lugano Stem Cell

Meeting 20th-21st June 2016

Università della Svizzera Italiana Lugano - Switzerland

R E G I S T R A T I O N F O R M

D E A D L I N E F O R R E G I S T R A T I O N

1S T J U N E 2 0 1 6

T O B E R E T U R N E D W I T H E N C L O S U R E S T O

Fondazione Cardiocentro Ticino Events and Communication Department

Via Tesserete 48 • CH-6900 Lugano

Phone +41 91 805 33 78 /31 93 - Fax +41 91 805 38 13 congressi@cardiocentro.org www.cardiocentro.org Family name Institute Department Institute Address Institute Postal code (int. Code: ++) e-mail First name City Tel. Country Fax

Registration fees Free registration for academy participants Euro 250 for industry participants

I would like to receive the brochure of the 9th Interventional Symposium on High Risk

and Innovative Cardiac Interventions – Meet the Experts 2016 Free registration for congress sponsors

Associated Institute of the University of Zurich

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