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The role of BRCA1 in homologous recombination repair in response to replication stress: significance in tumorigenesis and cancer therapy

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Figure 1 DSBs can be repaired by several HR repair pathways including DSBR (double-strand break repair) and SDSA (synthesis-dependent strand annealing)
Figure 2 Pathways of HR repair at stalled/ collapsed replication forks. (A,B,C) Possible pathways resolving leading-strand blockages by HR.Stalled replication forks can be cleaved by an endonuclease to generate a one-sided DSB (A) which can be repaired by
Figure 3 DNA lesions caused by PARP inhibitors lead to increased crossovers. DNA breaks are detected by PARP1 and PARP1 is activein response to DNA breaks

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