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VISPA: a computational pipeline for the identification and analysis of genomic vector integration sites

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Academic year: 2020

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Figure

Figure 1 IS analysis procedure for the Roche 454 sequencing platform. (A) DNA fragments containing the vector-cellular genome junctionsare retrieved and amplified from vector marked genomic DNA by LAM-PCR
Figure 2 Simplified architecture of the distributed alignment,filtering tool, control, and flow in the distributedimplementation
Figure 3 Schematic representation of the pipeline’s architecture. Interaction with the system happens through a Galaxy-based GUI: afterlogging in to the web site, the user is able to upload data and customize the various parameters using a dedicated subsec
Figure 4 Reliability evaluation of VISPA and other IS analysis tools. (A) Overall strategy for reliability assessment, from the generation of thesynthetic dataset to the final results
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1 Department of Ophthalmology, Keio University school of Medicine, Tokyo, Japan; 2 Department of Ophthalmology, Tohoku University graduate school of Medicine, Miyagi, Japan;