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The heat shock response in neurons and astroglia and its role in neurodegenerative diseases

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Figure

Fig. 1 Post-translational modifications of HSF1 in relation to the functional domains in the protein
Fig. 2 The activation of HSF1 and its binding to DNA is regulated by a multi-step pathway that involves nuclear accumulation, intramolecular andintermolecular protein interactions, and post-translational modifications
Table 1 List of Hsps and whether their expression is up-regulated (↑), down-regulated (↓), or not changed (No Δ) across rodentmodels of HD compared to transgenic WT or non-transgenic mouse controls
Fig. 3 Proposed summary of changes in the HSR and its components in polyQ-expanded Htt over-expression models of HD
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