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Lysozyme Enhances Renal Excretion of Advanced Glycation Endproducts In Vivo and Suppresses Adverse AGE-mediated Cellular Effects In Vitro: A Potential AGE Sequestration Therapy for Diabetic Nephropathy?

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Figure

Table 1.Effect of a 2-week course of LZ administration on physiological serum and urine characteristics of NODand db/db mice
Fig. 2.Lysozyme enhances macrophage binding, internalization and degradation of AGE formed or was immobilized on a NC membrane (10 in vitro or in human sera.(A) Confluent cultures of murine macrophage-like T1B-183 cells (0.5 �106/well) were incubated with e
Fig. 4.Lysozyme suppresses AGE-mediated synthesismedium (CL) in the presence or absence of LZ (100 for 48 hrs at 37TNFare expressed as the M three identical experiments, each done in duplicate
Table 2.LZ suppresses AGE-induced mesangial cell expression of growth promoting genes in culture§

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