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Prognostic Values of Filamin-A Status for Topoisomerase II Poison Chemotherapy

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Figure

Fig. 1. Filamin-A expression sensitizes cells to Topo II poisons. The following three pairs of isogenetic filamin-A proficient and deficient cell lines were used (see Materials and Methods for details): M2 (FLNa−) and A7 (FLNa+); C8161-Con (filamin-A contr
Table 1. IC50 for human melanoma cell and breast cancer cells.
Fig. 3. Drug influx of doxorubicin in melanoma A7 and M2 cells. The A7 (FLNa+) and M2 (FLNa−) cells were treated with 5μg/ml doxorubicin for 0, 10min and 30min, the intracellular concentration of doxorubicin was assessed by measuring red fluorescent signal
Fig. 4. Drug efflux in filamin-A proficient and deficient cells. The cells were treated with 1.0 μg/ml of doxorubicin for 10 min, then were fixed with cold 4% paraformaldehyde immediately or after 15 or 30 min incubation in drug-free medium
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