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PCBP1 inhibits the expression of oncogenic STAT3 isoform by targeting alternative splicing of STAT3 exon 23

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Figure

Figure 1. Screening of key motifs in STAT3 exon 23 and splicing factors which are responsible for regulating the alternative splicing of STAT3 exon 23.diagram of the alternative splicing pattern of human STAT3 exon 23
Figure 2. PCBP1 controls the alternative splicing of STAT3 exon 23.detected by RT-PCR
Figure 3. Downregulating the ratio of STAT3 α/β inhibits the cell growth of OSCC cell through overexpression of PCBP1
Figure 4. Overexpression of PCBP1 reduces the ratio of STAT3blot showed the overexpression of T7 tagged PCBP1 and the expression level of cellular STAT3α/β and suppresses the cell proliferation of a breast cancer cell line (MCF-7)
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