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The ER Glycoprotein Quality Control System

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Figure

Figure 1. CNX/CRT cycle. In the ER, the action of two enzymes, glucosidase II and UGGT, regulate the release and binding of glycoproteins to CNX/CRTproviding a unique quality control mechanism known as the CNX/CRT cycle (Helenius et al., 1997) for glycopro
Figure 2. Alignment of protein sequences from UGGTs in the C-terminal region of the protein
Table 1. List of diseases and ER quality control implications*

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