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Optimizing immunosuppression with mTOR inhibitors in renal transplant recipients

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Figure

Figure 1: Chemical structure of Sirolimus and Everolimus.
Figure 2: Schematic representation of oral administration of mTOR inhibitors, interaction with metabolic  enzymes and effect on blood levels
Figure 1: Mean everolimus whole blood concentration profile (0–6 hours after administration) of 3 mg  everolimus start dose (n = 20) determined in renal transplant recipients using fluorescence polarization  immunoassay (FPIA) and liquid chromatography–tan
Figure  5: Difference in dosage advice (fluorescence polarization immunoassay [FPIA] versus liquid  chromatography– tandem mass spectrometry [LC-MS/MS]) given in the study period showing range and mean  (0.04 mg)
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